| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | metolachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2378670 | Moreland DE, Corbin FT, Novitzky WP, Parker CE, Tomer KB: Metabolism of metolachlor by a microsomal fraction isolated from grain sorghum (Sorghum bicolor) shoots. Z Naturforsch C. 1990 May;45(5):558-64. The preparations had a cytochrome P-450 content that varied from approximately 90 to 150 pmol P-450/mg protein with cytochrome P-420 varying from 0 to 3% of the P-450 content. |
2(0,0,0,2) | Details |
| 16315095 | Kawahigashi H, Hirose S, Ozawa K, Ido Y, Kojima M, Ohkawa H, Ohkawa Y: Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants. Transgenic Res. 2005 Dec;14(6):907-17. We introduced two novel types of pig (Sus scrofa) cytochrome P450, CYP2B22 and CYP2C49, into rice plants (Oryza sativa L. cv. 'Nipponbare') to produce herbicide-tolerant plants and to confirm the metabolic activities of the cytochrome P450 species. CYP2B22 rice plants showed tolerance towards 12 herbicides including chlortoluron (100 microM), amiprofos-methyl (2.5 microM), pendimethalin (10 microM), metolachlor (2.5 microM), and esprocarb (20 microM). |
1(0,0,0,1) | Details |
| 18217708 | Hirose S, Kawahigashi H, Tagiri A, Ohkawa Y: Herbicide-induced anthocyanin accumulation in transgenic rice by expression of rice OSB2 under the control of rice CYP72A21 promoter. J Agric Food Chem. 2008 Feb 27;56(4):1259-63. Epub 2008 Jan 25. CYP72A21, a rice cytochrome P450 gene, is induced by chloroacetamide herbicides. Leaves of the transgenic plants turned red upon treatment with the chloroacetamide herbicides acetochlor, alachlor, and metolachlor. |
1(0,0,0,1) | Details |
| 16277416 | Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Phytoremediation of metolachlor by transgenic rice plants expressing human CYP2B6. J Agric Food Chem. 2005 Nov 16;53(23):9155-60. We introduced the human cytochrome P450 gene CYP2B6 into rice plants (Oryza sativa L. cv. |
1(0,0,0,1) | Details |
| 16608219 | Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Phytoremediation of the herbicides atrazine and metolachlor by transgenic rice plants expressing human CYP1A1, CYP2B6, and CYP2C19. J Agric Food Chem. 2006 Apr 19;54(8):2985-91. This study evaluated the expression of human cytochrome P450 genes CYP1A1, CYP2B6, and CYP2C19 in rice plants (Oryza sativa cv. |
1(0,0,0,1) | Details |
| 11133395 | Coleman S, Linderman R, Hodgson E, Rose RL: Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. Environ Health Perspect. 2000 Dec;108(12):1151-7. We have also shown that the cytochrome P450 isoforms responsible for human metabolism of acetochlor, butachlor, and metolachlor are CYP3A4 and CYP2B6. |
81(1,1,1,1) | Details |
| 18026775 | Jin-Clark Y, Anderson TD, Zhu KY: Effect of alachlor and metolachlor on toxicity of chlorpyrifos and major detoxification enzymes in the aquatic midge, Chironomus tentans (Diptera: Chironomidae). Arch Environ Contam Toxicol. 2008 May;54(4):645-52. Epub 2007 Nov 17. In contrast, metolachlor at 1,000 microg/L reduced protein production by 3.2-fold, which was associated with a 2.8-fold reduction of cytochrome P450 O-deethylation total activity and 1.4- to 1.7-fold reductions of GST total activities in the treated midges. |
81(1,1,1,1) | Details |
| 8820859 | Potter S, Moreland DE, Kreuz K, Ward E: Induction of cytochrome P450 genes by in maize. Drug Metabol Drug Interact. 1995;12(3-4):317-27. treatment of etiolated maize seedlings led to a marked enhancement in metabolism of the herbicides metolachlor and prosulfuron. cDNA clones representing eight genes that encode putative cytochrome P450 enzymes were isolated from maize. |
32(0,1,1,2) | Details |