Protein Information

Name ABCC
Synonyms ABC29; MRP; MRP1; ABCC; ABCC 1; ABCC1; ATP binding cassette subfamily C member1; ATP binding cassette sub family C member 1…

Compound Information

Name metolachlor
CAS

Reference List

PubMed Abstract RScore(About this table)
18433974 Oosterhuis B, Vukman K, Vagi E, Glavinas H, Jablonkai I, Krajcsi P: Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins. Toxicology. 2008 Jun 3;248(1):45-51. Epub 2008 Mar 14.

We tested the interaction of the herbicides acetochlor, alachlor, dimetachlor, metazachlor, metolachlor, propachlor and prynachlor with human multidrug resistance transporters MDR1, MRP1, MRP2 and BCRP.
33(0,1,1,3) Details
15133126 Geisler M, Girin M, Brandt S, Vincenzetti V, Plaza S, Paris N, Kobae Y, Maeshima M, Billion K, Kolukisaoglu UH, Schulz B, Martinoia E: Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Mol Biol Cell. 2004 Jul;15(7):3393-405. Epub 2004 May 7.

We were able to demonstrate that TWD1 binds to isolated vacuoles and has a significant impact on the uptake of metolachlor-GS and estradiol-beta-glucuronide, well-known substrates of vacuolar transporters AtMRP1 and AtMRP2.
AtMRP1, a multidrug resistance-associated (MRP/ABCC)-like ABC transporter, has been isolated in a yeast two-hybrid screen.
2(0,0,0,2) Details