Protein Information

Name CYP2B6
Synonyms CPB 6; CPB6; CYP2B; CYP2B protein; CYP2B6; CYPIIB 6; CYPIIB6; Cytochrome P450 2B6…

Compound Information

Name metolachlor
CAS

Reference List

PubMed Abstract RScore(About this table)
16277416 Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Phytoremediation of metolachlor by transgenic rice plants expressing human CYP2B6. J Agric Food Chem. 2005 Nov 16;53(23):9155-60.

We evaluated the degradation of metolachlor by CYP2B6 rice plants to confirm the metabolic activity of the introduced CYP2B6.
107(1,1,5,7) Details
15853388 Hirose S, Kawahigashi H, Ozawa K, Shiota N, Inui H, Ohkawa H, Ohkawa Y: Transgenic rice containing human CYP2B6 detoxifies various classes of herbicides. J Agric Food Chem. 2005 May 4;53(9):3461-7.

At germination, R (1) seeds of transgenic rice plants expressing CYP2B6 (CYP2B6 rice) showed a high tolerance to 5 microM metolachlor, a preemergence herbicide that is degraded by CYP2B6.
90(1,1,2,5) Details
11133395 Coleman S, Linderman R, Hodgson E, Rose RL: Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. Environ Health Perspect. 2000 Dec;108(12):1151-7.

We have also shown that the cytochrome P450 isoforms responsible for human metabolism of acetochlor, butachlor, and metolachlor are CYP3A4 and CYP2B6.
31(0,1,1,1) Details
16608219 Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Phytoremediation of the herbicides atrazine and metolachlor by transgenic rice plants expressing human CYP1A1, CYP2B6, and CYP2C19. J Agric Food Chem. 2006 Apr 19;54(8):2985-91.
7(0,0,1,2) Details
18685273 Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Transgenic rice plants expressing human p450 genes involved in xenobiotic metabolism for phytoremediation. J Mol Microbiol Biotechnol. 2008;15(2-3):212-9. Epub 2008 Jul 28.

Rice (Oryza sativa) is a good candidate for this purpose and has been transformed with genes encoding cytochrome P450 monooxygenases CYP1A1, CYP2B6, and CYP2C19.
Transgenic plants were able to remove atrazine and metolachlor from soil.
1(0,0,0,1) Details