Protein Information

Name calcium channel (protein family or complex)
Synonyms calcium channel

Compound Information

Name warfarin
CAS

Reference List

PubMed Abstract RScore(About this table)
19445778 Sarkees ML, Bavry AA: Acute coronary syndrome (unstable angina and non-ST elevation MI). Clin Evid. 2009 Jan 13;2009. pii: 0209.

CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: aspirin, beta-blockers, calcium channel blockers, clopidogrel, direct thrombin inhibitors, glycoprotein IIb/IIIa inhibitors (oral or intravenous), heparin (low molecular weight, unfractionated), nitrates, routine early cardiac catheterisation and revascularisation, statins, and warfarin.
31(0,1,1,1) Details
18789548 Velavan P, Khan NK, Goode K, Rigby AS, Loh PH, Komajda M, Follath F, Swedberg K, Madeira H, Cleland JG: Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey. Int J Cardiol. 2010 Jan 7;138(1):63-9. Epub 2008 Sep 11.

On multivariable analysis the following provided independent prognostic information: increasing age (OR per SD=1.5, 95% CI 1.4-1.6), severe LVSD (1.8, 1.5-2.1), serum creatinine (1.2, 1.2-1.3), sodium (0.9, 0.8-0.9), Hb (0.9, 0.8-0.9) and treatment with ACEI (0.5, 0.5-0.6), beta-blockers (0.7, 0.6-0.8), statins (0.6, 0.5-0.7), calcium channel blockers (0.7, 0.6-0.8), warfarin (0.5, 0.4-0.6), heparin (1.7, 1.4-1.9), anti-platelet drugs (0.6, 0.5-0.6) and need for inotropes (5.5, 4.6-6.6).
6(0,0,1,1) Details
18394447 Allen Lapointe NM, Sun JL, Kaplan S, d'Almada P, Al-Khatib SM: Rhythm versus rate control in the contemporary management of atrial fibrillation in-hospital. Am J Cardiol. 2008 Apr 15;101(8):1134-41. Epub 2008 Feb 7.

Warfarin use was greater in the rhythm-control group compared with the rate-control group (adjusted OR 1.56, 95% CI 1.52 to 1.60), and warfarin use was greater with a CHADS (2) score > or =2 (unadjusted OR 1.21, 95% CI 1.19 to 1.24).
Patients managed only with beta blockers, calcium channel blockers, or digoxin were categorized as receiving rate control.
1(0,0,0,1) Details
19188572 Gidal BE, French JA, Grossman P, Le Teuff G: Assessment of potential drug interactions in patients with epilepsy: impact of age and sex. Neurology. 2009 Feb 3;72(5):419-25.

RESULTS: Use of concomitant medications occurred in every age group and increased with age for both men and women (mean number of non-AEDs ranging from 2.41 to 7.67 in males aged 18-34 and 85+ years and from 4.04 to 7.05 in females aged 18-34 and 85+ years; p < 0.001 for age trend). beta-Hydroxy-beta-methylglutaryl-coenzyme A reductase inhibitors (statins), calcium channel blockers (CCBs), and selective serotonin reuptake inhibitors (SSRIs) were the most commonly used non-AED medications with the potential for adverse drug interactions.
Use of antipsychotics, tricyclic antidepressants, and warfarin was also noted in more than 10% of patients across different age groups.
1(0,0,0,1) Details
19050195 Kesselheim AS, Misono AS, Lee JL, Stedman MR, Brookhart MA, Choudhry NK, Shrank WH: Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: a systematic review and meta-analysis. JAMA. 2008 Dec 3;300(21):2514-26.

Clinical equivalence was noted in 7 of 7 RCTs (100%) of beta-blockers, 10 of 11 RCTs (91%) of diuretics, 5 of 7 RCTs (71%) of calcium channel blockers, 3 of 3 RCTs (100%) of antiplatelet agents, 2 of 2 RCTs (100%) of statins, 1 of 1 RCT (100%) of angiotensin-converting enzyme inhibitors, and 1 of 1 RCT (100%) of alpha-blockers.
Among narrow therapeutic index drugs, clinical equivalence was reported in 1 of 1 RCT (100%) of class 1 antiarrhythmic agents and 5 of 5 RCTs (100%) of warfarin.
1(0,0,0,1) Details
18690874 Steiropoulos P, Trakada G, Bouros D: Current pharmacological treatment of pulmonary arterial hypertension. . Curr Clin Pharmacol. 2008 Jan;3(1):11-9.


Conventional treatment is based on non-specific drugs (warfarin, oxygen, diuretics).
0(0,0,0,0) Details
18501274 Winterkorn JM, Mack P, Eggenberger E: Transient visual loss in a 60-year-old man. Surv Ophthalmol. 2008 May-Jun;53(3):301-5.


The patient was treated with warfarin, baby aspirin, and a calcium channel blocker and has not had a recurrence of permanent visual loss in 17 years.
0(0,0,0,0) Details
18708824 Aronow WS: Treatment of atrial fibrillation and atrial flutter: Part II. Cardiol Rev. 2008 Sep-Oct;16(5):230-9.


Unless transesophageal echocardiography has shown no thrombus in the left atrial appendage before cardioversion, oral warfarin should be given for 3 weeks before elective direct current or drug cardioversion of AF and continued for at least 4 weeks after maintenance of sinus rhythm.
0(0,0,0,0) Details