| 18840707 |
Park IK, Giovenzana C, Hughes TL, Yu J, Trotta R, Caligiuri MA: The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development. Blood. 2009 Mar 12;113(11):2470-7. Epub 2008 Oct 7.
Blocking the Axl-Gas6 interaction with a soluble Axl fusion protein (Axl-Fc) or the vitamin K inhibitor warfarin significantly diminished the absolute number and percentage of CD3 (-) CD56 (+) NK cells derived from human CD34 (+) HPCs cultured in the presence of IL-15, probably resulting in part from reduced phosphorylation of STAT5. |
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