Protein Information

Name growth arrest specific protein 6
Synonyms AXL receptor tyrosine kinase ligand; AXL stimulatory factor; AXLLG; AXSF; GAS 6; GAS6; Growth arrest specific 6; Growth arrest specific protein 6…

Compound Information

Name warfarin
CAS

Reference List

PubMed Abstract RScore(About this table)
19564549 Park JK, Theuer S, Kirsch T, Lindschau C, Klinge U, Heuser A, Plehm R, Todiras M, Carmeliet P, Haller H, Luft FC, Muller DN, Fiebeler A: Growth arrest specific protein 6 participates in DOCA-induced target-organ damage. Hypertension. 2009 Aug;54(2):359-64. Epub 2009 Jun 29.

Furthermore, because warfarin interferes with Gas 6 protein expression, the findings could be of clinical relevance for anticoagulant choices.
93(1,1,1,13) Details
18495950 Danziger J: Vitamin K-dependent proteins, warfarin, and vascular calcification. . Clin J Am Soc Nephrol. 2008 Sep;3(5):1504-10. Epub 2008 May 21.

Warfarin prevents the activation of MGP and Gas-6, and in animals, induces vascular calcification.
84(1,1,1,4) Details
19692494 McCann JC, Ames BN: Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?. Am J Clin Nutr. 2009 Oct;90(4):889-907. Epub 2009 Aug 19.

Results indicate that 5 VKD proteins that are required for coagulation had critical functions (knockouts were embryonic lethal), whereas the knockouts of 5 less critical VKD proteins [osteocalcin, matrix Gla protein (Mgp), growth arrest specific protein 6, transforming growth factor beta-inducible protein (Tgfbi or betaig-h3), and periostin] survived at least through weaning.
Genetic loss of less critical VKD proteins, dietary vitamin K inadequacy, human polymorphisms or mutations, and vitamin K deficiency induced by chronic anticoagulant (warfarin/coumadin) therapy are all linked to age-associated conditions: bone fragility after estrogen loss (osteocalcin) and arterial calcification linked to cardiovascular disease (Mgp).
1(0,0,0,1) Details