Protein Information

Name periostin
Synonyms OSF 2; OSF2; Osteoblast specific factor 2 (fasciclin I like); Osteoblast specific factor 2; PDLPOSTN; PN; POSTN; Periostin…

Compound Information

Name warfarin
CAS

Reference List

PubMed Abstract RScore(About this table)
19692494 McCann JC, Ames BN: Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?. Am J Clin Nutr. 2009 Oct;90(4):889-907. Epub 2009 Aug 19.

Results indicate that 5 VKD proteins that are required for coagulation had critical functions (knockouts were embryonic lethal), whereas the knockouts of 5 less critical VKD proteins [osteocalcin, matrix Gla protein (Mgp), growth arrest specific protein 6, transforming growth factor beta-inducible protein (Tgfbi or betaig-h3), and periostin] survived at least through weaning.
Genetic loss of less critical VKD proteins, dietary vitamin K inadequacy, human polymorphisms or mutations, and vitamin K deficiency induced by chronic anticoagulant (warfarin/coumadin) therapy are all linked to age-associated conditions: bone fragility after estrogen loss (osteocalcin) and arterial calcification linked to cardiovascular disease (Mgp).
1(0,0,0,1) Details
18450759 Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD, Galipeau J: Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. J Biol Chem. 2008 Jun 27;283(26):17991-8001. Epub 2008 Apr 30.

Carboxylation of periostin could be inhibited by warfarin in MSCs, demonstrating its dependence on the presence of vitamin K.
88(1,1,1,8) Details