Protein Information

Name GLUC
Synonyms CBG; CBG; GLUC; CBGL 1; CBGL1; Cytosolic beta glucosidase; Cytosolic beta glucosidase like protein 1; GBA 3…

Compound Information

Name warfarin
CAS

Reference List

PubMed Abstract RScore(About this table)
19788348 Jones DR, Moran JH, Miller GP: Warfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism. Drug Metab Rev. 2010;42(1):53-9.

Similarly, humans generated significant levels of glucuronides following treatment with warfarin. 7-O-GLUC was a major metabolite, while 6- and 8-O-GLUC were minor ones.		 82(1,1,1,2) Details
19408964 Miller GP, Jones DR, Sullivan SZ, Mazur A, Owen SN, Mitchell NC, Radominska-Pandya A, Moran JH: Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans. Chem Res Toxicol. 2009 Jul;22(7):1239-45.

As a step toward exploring a targeted metabolomics approach to personalized warfarin (Coumadin) therapy, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method capable of quantifying specific enantiomeric (R and S) contributions of warfarin (WAR) and the corresponding hydroxywarfarins (OH-WAR) and glucuronides (-GLUC) generated by cytochrome P450s (CYP) and UDP-glucuronosyltransferases (UGTs), respectively.		 32(0,1,1,2) Details