| 18568337 |
Onaran I, Sencan S, Demirtas H, Aydemir B, Ulutin T, Okutan M: Toxic-dose warfarin-induced apoptosis and its enhancement by gamma ionizing radiation in leukemia K562 and HL-60 cells is not mediated by induction of oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov;378(5):471-81. Epub 2008 Jun 21.
We report here that the increase of DCFH oxidation might be due to the increase in the release of cytochrome C caused by warfarin, as cytosolic cytochrome C content was significantly elevated in the warfarin-treated cells compared with control cells, and because cotreatment with antioxidants N- acetylcysteine or 4,5-dihydroxy-1,3-benzene-disulfonic acid (Tiron) was unable to prevent cytochrome C release and DCFH oxidation induced by the drug. |
31(0,1,1,1) |
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