| Name | albumin |
|---|---|
| Synonyms | ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619… |
| Name | warfarin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18721856 | Wybranowski T, Cyrankiewicz M, Ziomkowska B, Kruszewski S: The HSA affinity of warfarin and flurbiprofen determined by fluorescence anisotropy measurements of camptothecin. Biosystems. 2008 Dec;94(3):258-62. Epub 2008 Jul 31. A simple method based on measurements of fluorescence anisotropy of CPT-C allows to determine the affinity constant of CPT-C to HSA by computation of the fraction of bound CPT-C molecules with HSA It was observed, that adding of competing drug to plasma significant reduces the rate of increase of CPT-C fluorescence anisotropy with increase of albumin concentration and, the affinity constant of CPT-C to HSA decreases. |
1(0,0,0,1) | Details |
| 18307975 | Ascenzi P, Imperi F, Coletta M, Fasano M: Abacavir and warfarin modulate allosterically kinetics of NO dissociation from ferrous nitrosylated human serum heme-albumin. Biochem Biophys Res Commun. 2008 May 2;369(2):686-91. Epub 2008 Feb 26. |
0(0,0,0,0) | Details |
| 19017829 | Bird J, Carmona C: Probable interaction between warfarin and torsemide. . Ann Pharmacother. 2008 Dec;42(12):1893-8. Epub 2008 Nov 18. DISCUSSION: Both torsemide and warfarin are highly protein-bound to albumin and are major substrates for the CYP2C9 isoenzyme. |
162(2,2,2,2) | Details |
| 19691049 | Chu BL, Lin JM, Wang Z, Guo B: Enantiospecific binding of Rotigotine and its antipode to serum albumins: Investigation of binding constants and binding sites by partial-filling ACE. Electrophoresis. 2009 Aug;30(16):2845-52. The presence of either site marker (warfarin or ketoprofen) had adverse effect on the enantioseparation due to the competitive binding, or even eliminated the enantioselective binding of the enantiomers to the albumin when the molar ratio of the site marker to the albumin was at certain level. |
85(1,1,1,5) | Details |
| 19380237 | Abou-Khalil R, Jraij A, Magdalou J, Ouaini N, Tome D, Greige-Gerges H: Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands. J Photochem Photobiol B. 2009 Jun 3;95(3):189-95. Epub 2009 Mar 25. The increase of the K (a) values of warfarin and was associated with an increase of the binding constant value of cucurbitacin to albumin. |
84(1,1,1,4) | Details |
| 19902529 | Di Bari L, Ripoli S, Pradhan S, Salvadori P: Interactions between and Warfarin for albumin binding: A new eye on food/drug interference. Chirality. 2009 Nov 9. |
81(1,1,1,1) | Details |
| 18269390 | Reine PA, Kongsgaard UE, Andersen A, Thogersen AK, Olsen H: Infusion of albumin attenuates changes in serum protein binding of drugs in surgical patients compared with volume replacement with HAES. Acta Anaesthesiol Scand. 2008 Mar;52(3):406-12. The serum samples were analyzed to determine the concentrations of albumin, N-acetyl-dl- and alpha-1-acid glycoprotein as well as in vitro drug binding of warfarin and digitoxin. |
44(0,1,2,9) | Details |
| 18852190 | Jean G, Bresson E, Terrat JC, Vanel T, Hurot JM, Lorriaux C, Mayor B, Chazot C: Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences. Nephrol Dial Transplant. 2009 Mar;24(3):948-55. Epub 2008 Oct 13. The factors associated with VCs were classified into 'classic' (age, diabetes, male gender, tobacco use, inflammation, more frequent warfarin treatment and peripheral vascular and cardiac diseases) and 'non-traditional' (higher FGF-23 and OPG serum levels, low albumin serum levels and low alfacalcidol and CaCO (3) use). |
6(0,0,1,1) | Details |
| 18937368 | Basken NE, Mathias CJ, Green MA: Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals. J Pharm Sci. 2009 Jun;98(6):2170-9. The Cu-PTSM bis (N (4)-methylthiosemicarbazonato) (II)) and Cu-ATSM bis (N (4)-methylthiosemicarbazonato) (II)) radiopharmaceuticals exhibit strong, species-dependent binding to human serum albumin (HSA), while Cu-ETS (ethylglyoxal bis (thiosemicarbazonato) (II)) appears to only exhibit nonspecific binding to human and animal serum albumins. Warfarin, phenylbutazone, benzylpenicillin, and cephmandole were added to HSA solutions at drug:HSA mole ratios from 0 to 8:1, followed by quantification of radiopharmaceutical binding to HSA by ultrafiltration. |
3(0,0,0,3) | Details |
| 18421623 | Mukoyoshi M, Nishimura S, Hoshide S, Umeda S, Kanou M, Taniguchi K, Muroga H: In vitro drug-drug interaction studies with febuxostat, a novel non- selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition. Xenobiotica. 2008 May;38(5):496-510. The results have shown that the presence of or warfarin did not change the plasma protein binding of febuxostat, and that febuxostat did not influence the plasma protein binding of or warfarin. These results indicate that there is little possibility that febuxostat causes a drug-drug interaction by binding to albumin. 3. |
1(0,0,0,1) | Details |
| 20089378 | Trynda-Lemiesz L, Wiglusz K: Interactions of human serum albumin with meloxicam: characterization of binding site. J Pharm Biomed Anal. 2010 Jun 5;52(2):300-4. Epub 2010 Jan 4. Here, we report the effect of new generation, non-steroidal anti-inflammatory drug (NSAID) meloxicam on the albumin conformation and ligand binding. This was confirmed by the destabilization of the warfarin binding site. |
2(0,0,0,2) | Details |
| 19502106 | Sen P, Fatima S, Ahmad B, Khan RH: Interactions of thioflavin T with serum albumins: spectroscopic analyses. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Sep 15;74(1):94-9. Epub 2009 May 22. Its binding constant is comparable to many drugs that bind at domain II of HSA, like warfarin, digitoxin, etc. |
2(0,0,0,2) | Details |
| 18475961 | Trynda-Lemiesz L, Kozlowski H, Katsaros N: Interaction of Cis- and Trans-RuCl (2)(DMSO)(4) With Human Serum Albumin. . Met Based Drugs. 2000;7(6):293-9. The interaction between cis- and trans- RuCl (2)(DMSO)(4) and human serum albumin have been investigated through UV-Vis, circular dichroism, fluorescence spectroscopy and inductively couplet plasma atomic emission spectroscopy (ICP (AES)) method Albumin can specifically bind 1 mole of cis-isomer and 2 moles of the trans-isomer RuCl (2)(DMSO)(4) complex. The interaction of RuCl (2)(DMSO)(4) with HSA causes: a conformational change with the loss of helical stability of protein; the strong quenching of the Trp 214 fluorescence indicating that the conformational change of the hydrophobic binding pocked in subdomain IIA takes place; a local perturbation of the warfarin binding site and induce some conformational changes at neighbour domains, a changing of the binding abilities towards heme. |
1(0,0,0,1) | Details |