Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name warfarin
CAS

Reference List

PubMed Abstract RScore(About this table)
18772604 Kurohara M, Yasuda H, Moriyama H, Nakayama M, Sakata M, Yamada K, Kotani R, Hara K, Yokono K, Nagata M: Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes. Kobe J Med Sci. 2008 May 23;54(1):E1-13.

As low-dose warfarin has been reported to have anti-inflammatory effect through suppression of IL-6 secretion and inhibit the immune-associated signal between Tyro3 and its ligand, Gas6, the effect of low-dose warfarin on autoimmune diabetes in NOD mice was examined.
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19564549 Park JK, Theuer S, Kirsch T, Lindschau C, Klinge U, Heuser A, Plehm R, Todiras M, Carmeliet P, Haller H, Luft FC, Muller DN, Fiebeler A: Growth arrest specific protein 6 participates in DOCA-induced target-organ damage. Hypertension. 2009 Aug;54(2):359-64. Epub 2009 Jun 29.

Furthermore, because warfarin interferes with Gas 6 protein expression, the findings could be of clinical relevance for anticoagulant choices.
Cardiac expression of interleukin 6 and collagen IV was blunted in Gas 6 (-/-) mice, indicating reduced inflammation and fibrosis.
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19535655 Fetterman JW Jr, Zdanowicz MM: Therapeutic potential of n-3 polyunsaturated fatty acids in disease. Am J Health Syst Pharm. 2009 Jul 1;66(13):1169-79.

Likewise, n-3 PUFAs can also reduce the production of inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1, and interleukin-6.
When recommending an n-3 PUFA, clinicians should be aware of any possible adverse effect or drug interaction that, although not necessarily clinically significant, may occur, especially for patients who may be susceptible to increased bleeding (e.g., patients taking warfarin).
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19682232 Wannamethee SG, Whincup PH, Shaper AG, Rumley A, Lennon L, Lowe GD: Circulating inflammatory and hemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not angina pectoris, in older men. J Thromb Haemost. 2009 Oct;7(10):1605-11. Epub 2009 Aug 11.


METHODS: A prospective study of 3217 men aged 60-79 years with no baseline CHD (angina or MI) and who were not on warfarin, followed up for 7 years during which there were 198 MI/CHD death cases and 220 incident uncomplicated angina cases.
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