Protein Information

Name CYP1A1
Synonyms AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1…

Compound Information

Name warfarin
CAS

Reference List

PubMed Abstract RScore(About this table)
19577456 Wu WW, Yeung JH: Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo. Phytomedicine. 2010 Mar;17(3-4):219-26. Epub 2009 Jul 3.

In rat liver microsomes study, the ethyl acetate extract of Danshen, tanshinone I, tanshinone IIA and cryptotanshinone decreased the formation of 4'-, 6- and 7-hydroxy-warfarin, mediated by CYP1A1, CYP2C6 and CYP2C11 activities, respectively.
82(1,1,1,2) Details