| Name | matrix Gla protein |
|---|---|
| Synonyms | GIG36; MGLAP; MGP; Matrix Gla protein; Matrix Gla protein precursor; Matrix gamma carboxyglutamic acid protein; NTI; Matrix Gla proteins… |
| Name | warfarin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19847375 | Villines TC, O'Malley PG, Feuerstein IM, Thomas S, Taylor AJ: Does prolonged warfarin exposure potentiate coronary calcification in humans? Results of the warfarin and coronary calcification study. Calcif Tissue Int. 2009 Dec;85(6):494-500. Epub 2009 Oct 22. Warfarin has been shown to accelerate vascular calcification in experimental animals, and possibly humans, through inhibition of the -dependent protein matrix gla protein, a potent inhibitor of tissue calcification. |
81(1,1,1,1) | Details |
| 19793187 | Lerner RG, Aronow WS, Sekhri A, Palaniswamy C, Ahn C, Singh T, Sandhu R, McClung JA: Warfarin use and the risk of valvular calcification. J Thromb Haemost. 2009 Dec;7(12):2023-7. Epub 2009 Sep 28. BACKGROUND: Warfarin affects the synthesis and function of the matrix Gla-protein, a -dependent protein, which is a potent inhibitor of tissue calcification. |
81(1,1,1,1) | Details |
| 19350115 | Koos R, Krueger T, Westenfeld R, Kuhl HP, Brandenburg V, Mahnken AH, Stanzel S, Vermeer C, Cranenburg EC, Floege J, Kelm M, Schurgers LJ: Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification. Thromb Haemost. 2009 Apr;101(4):706-13. |
2(0,0,0,2) | Details |
| 19884975 | Kohn MH, Price RE, Pelz HJ: A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats. Artery Res. 2008 Nov;2(4):138-147. The undercarboxylation of the -dependent Matrix Gla protein may be the crucial component of the pathway promoting this mineralization. |
1(0,0,0,1) | Details |
| 19692494 | McCann JC, Ames BN: an example of triage theory: is micronutrient inadequacy linked to diseases of aging?. Am J Clin Nutr. 2009 Oct;90(4):889-907. Epub 2009 Aug 19. Results indicate that 5 VKD proteins that are required for coagulation had critical functions (knockouts were embryonic lethal), whereas the knockouts of 5 less critical VKD proteins [osteocalcin, matrix Gla protein (Mgp), growth arrest specific protein 6, transforming growth factor beta-inducible protein (Tgfbi or betaig-h3), and periostin] survived at least through weaning. Genetic loss of less critical VKD proteins, dietary inadequacy, human polymorphisms or mutations, and vitamin K deficiency induced by chronic anticoagulant (warfarin/ therapy are all linked to age-associated conditions: bone fragility after loss (osteocalcin) and arterial calcification linked to cardiovascular disease (Mgp). |
1(0,0,0,1) | Details |
| 18495950 | Danziger J: -dependent proteins, warfarin, and vascular calcification. . Clin J Am Soc Nephrol. 2008 Sep;3(5):1504-10. Epub 2008 May 21. Matrix Gla Protein (MGP) and Growth Arrest Specific Gene 6 (Gas-6) are two particularly important VKDPs, and their roles in vascular biology are just beginning to be understood. |
1(0,0,0,1) | Details |
| 18369157 | Yao Y, Shahbazian A, Bostrom KI: and gamma-carboxylated residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4. Circ Res. 2008 May 9;102(9):1065-74. Epub 2008 Mar 27. Chelation of ions by EDTA or warfarin treatment of cells led to loss of ability of MGP to bind BMP-4. |
1(0,0,0,1) | Details |
| 19910445 | Cai Y, Xu MJ, Teng X, Zhou YB, Chen L, Zhu Y, Wang X, Tang CS, Qi YF: Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. Cardiovasc Res. 2010 Mar 1;85(4):864-73. Epub 2009 Nov 12. However, the inhibitory effects of IMD on VC were eliminated upon pre-treatment with warfarin or small interfering RNA to reduce cMGP. |
1(0,0,0,1) | Details |