Protein Information

Name glutamyl transpeptidase
Synonyms CD224; CD224 antigen; D22S672; D22S732; GGT; GGT 1; GGT1; GGT1 protein…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
233 Ivanov E, Krustev L, Adjarov D, Chernev K, Apostolov I, Dimitrov P, Drenska E, Stefanova M, Pramatarova V: Studies on the mechanism of the changes in serum and liver gamma-glutamyl transpeptidase activity. Enzyme. 1976;21(1):8-20.

The mechanism responsible for the changes in serum and liver gamma-glutamyl transpeptidase (gamma-GT) activity was studied in a model of experimental hexachlorobenzene porphyria in rabbits.
43(0,1,2,8) Details
6124055 Adjarov D, Ivanov E, Keremidchiev D: Gamma-glutamyl transferase: a sensitive marker in experimental hexachlorobenzene intoxication. Toxicology. 1982;23(1):73-7.
16(0,0,2,6) Details
6142762 Manson MM, Smith AG: Effect of hexachlorobenzene on male and female rat hepatic gamma-glutamyl transpeptidase levels. Cancer Lett. 1984 Mar;22(2):227-34.
12(0,0,2,2) Details
2885267 Ivanov E, Savov G, Adjarov D: Changes in some intestinal enzyme activities in experimental hexachlorobenzene-induced porphyria and modifying effects of diet. IARC Sci Publ. 1986;(77):611-8.

As HCB and its metabolites come into direct contact with intestinal mucosa, this study investigated the changes in the activities of intestinal disaccharidases and gamma-glutamyl transferase in a model of HCB-induced porphyria.
2(0,0,0,2) Details
6112130 Chernev K, Ivanov E, Adzharov D: [Induction of mixed microsomal oxidase in experimental hexachlorobenzene porphyria in rabbits]. Eksp Med Morfol. 1981;20(1):8-11.

The mitochondrial enzyme Deltaaminolevuline acid-syntatese (DALA-syntatase) is determined in liver homogenate as well as the enzyme gamma-glutamyl-transpeptidase (GGTP) in serum and uro- and coproporphyrines in urine.
1(0,0,0,1) Details
8330354 Smith AG, Carthew P, Francis JE, Cabral JR, Manson MM: Enhancement by iron of hepatic neoplasia in rats caused by hexachlorobenzene. Carcinogenesis. 1993 Jul;14(7):1381-7.

These hyperplastic regions were depleted of iron and were often positive for gamma-glutamyl transpeptidase (GGT) and glutathione S-transferase P (GST-P).
1(0,0,0,1) Details
11171930 Sala M, Sunyer J, Herrero C, To-Figueras J, Grimalt J: Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population. Occup Environ Med. 2001 Mar;58(3):172-7.

METHODS: Thyroid stimulating hormone (TSH), total and free thyroxine (T4), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were measured as biological markers of thyroid and liver function in a rural population sample older than 14 years (n=192, except for TSH with n=608) highly exposed to HCB.
1(0,0,0,1) Details