Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
12038708 Iscan M, Coban T, Cok I, Bulbul D, Eke BC, Burgaz S: The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association?. Breast Cancer Res Treat. 2002 Mar;72(2):173-82.

The levels of some organochlorine pesticides (OCP) s (hexachlorobenzene, HCB, alpha-hexachlorocyclohexane, alpha-HCH, beta-HCH, gamma-HCH, heptachlorepoxide, HE, bis (4-chlorophenyl)-1,1-dichloroethene, p.p'DDE, bis (4-chlorophenyl)-1,1,1-trichloroethane, p.p' DDT and total DDT (E-DDT) and antioxidant enzyme activities namely Cu, Zn superoxide dismutase (SOD), catalase (CAT), selenium-dependent glutathione peroxidase (Se-GSH-Px), total glutathione peroxidase (T-GSH-Px), selenium independent glutathione peroxidase (GSH-Px II), glutathione reductase (GRd), level of reduced glutathione (GSH) and lipid peroxidation (LP), glutathione S-transferase (GST) activity toward several substrates including 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethacrynic acid (EAA), 1,2-epoxy-3-(p-nitrophenoxy)-propane (ENPP) were measured in tumor and surrounding tumor free tissues of 24 female breast cancer patients and was evaluated whether there exist any association between the levels of OCPs and antioxidants.
31(0,1,1,1) Details
3236339 Rizzardini M, Graziani A, Carugo C, Cantoni L: Investigations on the role of free radical processes in hexachlorobenzene-induced porphyria in mice. J Biochem Toxicol. 1988 Spring;3:33-45.

A synergistic effect of iron was evident on other parameters too, such as HCB-induced hepatic damage, activation of type O of xanthine oxidase, and decreased activity of copper zinc superoxide dismutase and glutathione peroxidase (s).
1(0,0,0,1) Details
16089327 Liu W, Li P, Zhou Q, Sun T, Tai P, Xu H: Short-term toxic effects of chlorobenzenes on broadbean (Vicia faba) seedlings. Sci China C Life Sci. 2005 May;48 Suppl 1:33-9.


The root growth, changes in superoxide dismutase (SOD, EC 1.15.1.1) activity, malonyldialdehyde (MDA) and total soluble protein level of broadbean (Vicia faba) seedlings were researched at different soil concentrations of chlorobenzene (CB), 1,2,4-trichlorobenzene (TCB) and hexachlorobenzene (HCB).
1(0,0,0,1) Details
17096944 Li YF, Shi N, Li HY, Liu YS, Sun M, Hu FY: [Toxicity and oxidative stress on rats by hexachlorobenzene] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Oct;24(10):601-4.

The content of malondialdehyde (MDA) and the activity of total-superoxide dismutase (T-SOD), catalase (CAT) and glutathione peroxidase (GSH-PX) in cerebral cortex, hippocampus, liver tissue and serum were determined.
1(0,0,0,1) Details
19954812 Faria M, Huertas D, Soto DX, Grimalt JO, Catalan J, Riva MC, Barata C: Contaminant accumulation and multi-biomarker responses in field collected zebra mussels (Dreissena polymorpha) and crayfish (Procambarus clarkii), to evaluate toxicological effects of industrial hazardous dumps in the Ebro river (NE Spain). Chemosphere. 2010 Jan;78(3):232-40. Epub 2009 Dec 1.

Biological responses included levels of metallothioneins, activities of ethoxyresorufin-O-deethylase, oxidative stress biomarkers (glutathione content, enzymatic activities of superoxide dismutase, catalase, glutathione s-transferase, glutathione peroxidise and glutathione reductase), levels of lipid peroxidation and of DNA strand breaks.
The aforementioned stress levels could be related with concentrations of mercury, cadmium, hexachlorobenzene, polychlorobiphenyls and dichlorodiphenyltrichloroethanes from 4- to 195-fold greater than local background levels.
1(0,0,0,1) Details
9192204 Almeida MG, Fanini F, Davino SC, Aznar AE, Koch OR, Barros SB: Pro- and anti-oxidant parameters in rat liver after short-term exposure to hexachlorobenzene. Hum Exp Toxicol. 1997 May;16(5):257-61.

Concomitantly, liver antioxidant defenses are slightly modified, with decreased activity of glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase contributing to an oxidative stress condition of the liver.
1(0,0,0,1) Details
16978756 Chaufan G, Juarez A, Basack S, Ithuralde E, Sabatini SE, Genovese G, Oneto ML, Kesten E, Rios de Molina Mdel C: Toxicity of hexachlorobenzene and its transference from microalgae (Chlorella kessleri) to crabs (Chasmagnathus granulatus). Toxicology. 2006 Oct 29;227(3):262-70. Epub 2006 Aug 18.

Antioxidant defenses such as superoxide dismutase activity and reduced glutathione content fell below normal values on the fourth week of treatment.
1(0,0,0,1) Details
10410240 de Catabbi SB, de Calmanovici RW, Minutolo C, Aldonatti C, San Martin de Viale LC: Porphyria-induced hepatic porphyrinogen carboxy-lyase inhibitor and its interaction with the active site (s) of the enzyme. Biochem Mol Biol Int. 1999 Jun;47(6):945-56.


In mammals this enzyme activity is impaired by hexachlorobenzene treatment, through generation of an enzyme inhibitor.
0(0,0,0,0) Details
16497358 Song SB, Xu Y, Zhou BS: Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio). Chemosphere. 2006 Oct;65(4):699-706. Epub 2006 Feb 23.

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