Protein Information

Name POLL
Synonyms DNA polymerase beta 2; DNA polymerase kappa; DNA polymerase beta N; DNA polymerase lambda; DNA polymerase lamda2; POL KAPPA; POLL; Pol Lambda…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
19335881 Langer P, Kocan A, Tajtakova M, Susienkova K, Radikova Z, Koska J, Ksinantova L, Imrich R, Huckova M, Drobna B, Gasperikova D, Trnovec T, Klimes I: Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin). Thyroid Res. 2009 Mar 31;2(1):3.

METHODS: In a total of 2046 adults (834 males and 1212 females; age range 21-75) from POLL and BCGR the serum level of major POPs such as of 15 most abundant PCBs congeners, dichlorodiphenyl-dichloroethylene (p,p'-DDE) and hexachlorobenzene (HCB) was estimated by high resolution gas chromatography.
10(0,0,1,5) Details
18790515 Langer P, Kocan A, Tajtakova M, Koska J, Radikova Z, Ksinantova L, Imrich R, Huckova M, Drobna B, Gasperikova D, Sebokova E, Klimes I: Increased thyroid volume, prevalence of thyroid antibodies and impaired fasting glucose in young adults from organochlorine cocktail polluted area: outcome of transgenerational transmission?. Chemosphere. 2008 Oct;73(7):1145-50. Epub 2008 Sep 14.


In 137 females (F) and 94 males (M) aged 21-35 years from organochlorines (OCs) polluted area (POLL) increased thyroid volume (ThV), prevalence of antibodies to thyroperoxidase (TPOab), thyrotropin receptor (TRab) and of impaired fasting glucose (IFG) was found compared to 116 F and 107 M from background pollution area (BCGR).
5(0,0,0,5) Details
17692893 Langer P, Kocan A, Tajtakova M, Radikova Z, Petrik J, Koska J, Ksinantova L, Imrich R, Huckova M, Chovancova J, Drobna B, Jursa S, Bergman A, Athanasiadou M, Hovander L, Gasperikova D, Trnovec T, Sebokova E, Klimes I: Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary-thyroid interrelations. Chemosphere. 2007 Nov;70(1):110-8. Epub 2007 Aug 10.

In polluted district of Michalovce in East Slovakia (POLL) and two districts with background pollution (BCGR) 2046 adults (834 males and 1212 females aged 20-75 years) were examined.
Serum levels of thyrotropin (TSH), free thyroxine (FT4), total triiodothyronine (TT3) and antithyroperoxidase antibodies (TPOab) were estimated by electrochemiluminiscent assay and also these of 15 polychlorinated biphenyl congeners (PCBs), p,p'-DDE, p,p'-DDT, hexachlorobenzene (HCB) and hexachlorocyclohexane were measured by high resolution gas chromatography/mass spectrometry.
3(0,0,0,3) Details
19856712 Cebecauer L, Radikova Z, Rovensky J, Koska, Imrich R, Ksinantova L, Susienkova K, Vigas M, Klimes I, Langer P: Increased prevalence and coincidence of antinuclear and antithyroid antibodies in the population exposed to high levels of polychlorinated pollutants cocktail. Endocr Regul. 2009 Apr;43(2):75-81.

METHODS: Antinuclear antibodies. (ANA) were estimated by indirect immunofluorescence test using Hep2- cells and thyroperoxidase antibodies (TPOab) by electrochemiluminiscent immunoassay in the cohort of 253 adults (82 males and 171 females) aged 21-75 years, among them 144 (46 males and 98 females) from the area polluted (POLL) by polychlorinated biphenyls (PCB) and 109 (36 males and 73 females) from the area of background pollutrion (BCGR).
In the same cohort fifteen congeners of PCB and also total DDE (2,2'-bis (4-chlorophenyl)-1,1-dichloroethylene) and hexachlorobenzene (HCB) were estimated by high resolution gas chromatography/mass spectrometry.
3(0,0,0,3) Details
17537484 Langer P, Tajtakova M, Kocan A, Petrik J, Koska J, Ksinantova L, Radikova Z, Ukropec J, Imrich R, Huckova M, Chovancova J, Drobna B, Jursa S, Vlcek M, Bergman A, Athanasiadou M, Hovander L, Shishiba Y, Trnovec T, Sebokova E, Klimes I: Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin. Chemosphere. 2007 Aug;69(1):118-27. Epub 2007 May 29.

We examined 2,046 adults (834 males and 1,212 females aged 20-75 years) from polluted district in East Slovakia (POLL) and two neighboring upstream and upwind located districts of background pollution (BCGR).
Serum levels of thyrotropin (TSH), thyroperoxidase antibodies (TPOab) and thyroglobulin were estimated by electrochemiluminiscent assay and these of 15 PCB congeners, p,p'-DDE, p,p'-DDT, hexachlorobenzene (HCB) and hexachlorocyclohexane by high-resolution gas chromatography.
2(0,0,0,2) Details