| Name | Glutathione S transferase pi |
|---|---|
| Synonyms | DFN 7; PI; DFN7; FAEES 3; FAEES3; GST class pi; GST3; GSTP 1… |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10696772 | Gustafson DL, Long ME, Thomas RS, Benjamin SA, Yang RS: Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: application of a medium-term liver focus bioassay and molecular and cellular indices. Toxicol Sci. 2000 Feb;53(2):245-52. In the studies presented here, we measured the ability of 1,4-dichlorobenzene (DCB), 1,2,4,5-tetrachlorobenzene (TeCB), pentachlorobenzene (PeCB), and hexachlorobenzene (HCB) to promote glutathione S-transferase pi (GSTP1-1) positive preneoplastic foci formation in rat liver, following diethylnitrosamine (DEN) initiation. |
9(0,0,1,4) | Details |
| 17874069 | Lu Y, Lohitnavy M, Reddy M, Lohitnavy O, Eickman E, Ashley A, Gerjevic L, Xu Y, Conolly RB, Yang RS: Quantitative analysis of liver GST-P foci promoted by a chemical mixture of hexachlorobenzene and PCB 126: implication of size-dependent cellular growth kinetics. Arch Toxicol. 2008 Feb;82(2):103-16. Epub 2007 Sep 14. The objectives of this study were twofold: (1) evaluating the carcinogenic potential of the mixture of two persistent environmental pollutants, hexachlorobenzene (HCB) and 3,3',4,4',5-pentachlorobiphenyl (PCB 126), in an initiation-promotion bioassay involving the development of pi glutathione S-transferase (GST-P) liver foci, and (2) analyzing the GST-P foci data using a biologically-based computer model (i.e., clonal growth model) with an emphasis on the effect of focal size on the growth kinetics of initiated cells. |
6(0,0,1,1) | Details |
| 12700395 | Ou YC, Conolly RB, Thomas RS, Gustafson DL, Long ME, Dobrev ID, Chubb LS, Xu Y, Lapidot SA, Andersen ME, Yang RS: Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Toxicol Sci. 2003 Jun;73(2):301-14. Epub 2003 Apr 15. A combination of experimental and simulation approaches was used to analyze clonal growth of glutathione-S-transferase pi (GST-P) enzyme-altered foci during liver carcinogenesis in an initiation-promotion regimen for 1,4-dichlorobenzene (DCB), 1,2,4,5-tetrachlorobenzene (TECB), pentachlorobenzene (PECB), and hexachlorobenzene (HCB). |
1(0,0,0,1) | Details |
| 9806169 | Thomas RS, Gustafson DL, Pott WA, Long ME, Benjamin SA, Yang RS: Evidence for hepatocarcinogenic activity of pentachlorobenzene with intralobular variation in foci incidence. Carcinogenesis. 1998 Oct;19(10):1855-62. Pentachlorobenzene (PeCB) is an important environmental contaminant derived primarily from the by-product contamination of the popular fungicides hexachlorobenzene and pentachloronitrobenzene. Results showed that PeCB, at both doses, significantly increased both the number and area of glutathione S-transferase pi (GST-P) foci (> 0.2 mm diameter) (P < 0.05). |
1(0,0,0,1) | Details |
| 11280742 | Ou YC, Conolly RB, Thomas RS, Xu Y, Andersen ME, Chubb LS, Pitot HC, Yang RS: A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res. 2001 Mar 1;61(5):1879-89. Experimental data including liver weight, hepatocyte density (number of hepatocytes/unit volume), 5-bromo-2'--labeling index for analysis of cell division rate, and number and volume of glutathione-S-transferase pi-positive foci were collected 23, 26, 28, 47, or 56 days after initiation. |
1(0,0,0,1) | Details |
| 8330354 | Smith AG, Carthew P, Francis JE, Cabral JR, Manson MM: Enhancement by iron of hepatic neoplasia in rats caused by hexachlorobenzene. Carcinogenesis. 1993 Jul;14(7):1381-7. These hyperplastic regions were depleted of iron and were often positive for gamma-glutamyl transpeptidase (GGT) and glutathione S-transferase P (GST-P). |
1(0,0,0,1) | Details |
| 7683635 | Tsuda H, Matsumoto K, Ogino H, Ito M, Hirono I, Nagao M, Sato K, Cabral R, Bartsch H: Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens. Jpn J Cancer Res. 1993 Mar;84(3):230-6. In Experiment 2, group 1 rats were subjected to PH and 12 h later received a suspected carcinogenic mixture of opium pyrolysate (OP) or carcinogenic pesticide p,p'-dichloro-diphenyltrichloroethane or hexachlorobenzene. |
1(0,0,0,1) | Details |