| Name | thyroid stimulating hormone (protein family or complex) |
|---|---|
| Synonyms | Thyroid stimulating hormone |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8240387 | van Raaij JA, Frijters CM, van den Berg KJ: Hexachlorobenzene-induced hypothyroidism. Biochem Pharmacol. 1993 Oct 19;46(8):1385-91. The effects on thyroid hormone status were more pronounced after 4 weeks and also included increased thyroid stimulating hormone (TSH) levels. |
1(0,0,0,1) | Details |
| 11171930 | Sala M, Sunyer J, Herrero C, To-Figueras J, Grimalt J: Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population. Occup Environ Med. 2001 Mar;58(3):172-7. METHODS: Thyroid stimulating hormone (TSH), total and free (T4), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were measured as biological markers of thyroid and liver function in a rural population sample older than 14 years (n=192, except for TSH with n=608) highly exposed to HCB. |
1(0,0,0,1) | Details |
| 18087600 | Maervoet J, Vermeir G, Covaci A, Van Larebeke N, Koppen G, Schoeters G, Nelen V, Baeyens W, Schepens P, Viaene MK: Association of thyroid hormone concentrations with levels of organochlorine compounds in cord blood of neonates. Environ Health Perspect. 2007 Dec;115(12):1780-6. METHODS: We measured concentrations of environmental pollutants [including selected PCBs, dioxin-like compounds, hexachlorobenzene, p,p'-DDE (dichlorodiphenyldichloroethylene), cadmium, lead] and thyroid hormones in the cord blood of 198 neonates. |
0(0,0,0,0) | Details |
| 14750556 | Sugiura-Ogasawara M, Ozaki Y, Sonta S, Makino T, Suzumori K: PCBs, hexachlorobenzene and DDE are not associated with recurrent miscarriage. Am J Reprod Immunol. 2003 Dec;50(6):485-9. |
0(0,0,0,0) | Details |
| 19590699 | Dallaire R, Muckle G, Dewailly E, Jacobson SW, Jacobson JL, Sandanger TM, Sandau CD, Ayotte P: Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants. Environ Health Perspect. 2009 Jun;117(6):1014-20. Epub 2009 Jan 29. METHODS: We measured thyroid hormone parameters [thyroid stimulating hormone (TSH), free (fT (4)), total (T (3)), thyroxine-binding globulin (TBG)] and concentrations of several contaminants [PCB-153, hydroxylated metabolites of PCBs (HO-PCBs), pentachlorophenol (PCP) and hexachlorobenzene (HCB)] in maternal plasma at delivery (n = 120), in umbilical cord plasma (n = 95), and in infant plasma at 7 months postpartum (n = 130). |
31(0,1,1,1) | Details |
| 19707252 | Lopez-Espinosa MJ, Vizcaino E, Murcia M, Fuentes V, Garcia AM, Rebagliato M, Grimalt JO, Ballester F: Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels. J Expo Sci Environ Epidemiol. 2009 Aug 26. The main aim of this study was to examine the relationship of cord serum levels of 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane (4,4'-DDT), 1,1-dichloro-2,2-bis (4-chlorophenyl) ethylene (4,4'-DDE), beta-hexachlorocyclohexane (beta-HCH), hexachlorobenzene (HCB), four individual polychlorobiphenyl (PCB) congeners (118, 138, 153, and 180), and their sum, with neonatal thyroid stimulating hormone (TSH) levels in blood samples in a mother-infant cohort in Valencia, Spain. |
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| 12011480 | Wade MG, Parent S, Finnson KW, Foster W, Younglai E, McMahon A, Cyr DG, Hughes C: Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol Sci. 2002 Jun;67(2):207-18. To investigate the potential effects of a complex, environmentally relevant mixture on the HPT axis, sexually mature male rats were administered a mixture of 16 common organochlorines (dichlorodiphenoxytrichloroethane [DDT], p,p'-dichlorodiphenoxydichloroethylene [p,p'-DDE], hexachlorobenzene [HCB], tetrachlorodibenzo-p-dioxin [TCDD], polychlorinated biphenyls [PCBs], methoxychlor, endosulfan, heptachlor, hexachlorocyclohexane, dieldrin, aldrin, mirex, and several chlorinated benzenes, and metal contaminants [lead, cadmium]). After 70 daily treatments by gavage, endpoints related to circulating thyroid hormone (serum [T (4)], [T (3)], thyroid stimulating hormone [TSH], and serum T (3) uptake [T (3)-up]), thyroid gland histomorphology (thyroid follicle cross sectional area, epithelial height, follicle roundness or aspect ratio, colloid/epithelial ratio) and hepatic metabolism of thyroid hormone (UDP-glucuronyl transferase [UGT] and outer-ring deiodinase [ORD]) were assessed. |
1(0,0,0,1) | Details |
| 17189629 | Meeker JD, Altshul L, Hauser R: Serum PCBs, p,p'-DDE and HCB predict thyroid hormone levels in men. Environ Res. 2007 Jun;104(2):296-304. Epub 2006 Dec 26. Abbreviations: BMI, body mass index; CYP, cytochrome P450; DDT, 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane; HCB, hexachlorobenzene; MDL, method detection limit; NHANES, national health and nutrition examination survey: p,p (')-DDE, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene; PCB, polychlorinated biphenyl; T (3), T (4), thryoxine; TSH, thyroid stimulating hormone (thyrotrophin); US, United States. |
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| 12660379 | Ribas-Fito N, Sala M, Cardo E, Mazon C, De Muga ME, Verdu A, Marco E, Grimalt JO, Sunyer J: Organochlorine compounds and concentrations of thyroid stimulating hormone in newborns. Occup Environ Med. 2003 Apr;60(4):301-3. |
2(0,0,0,2) | Details |
| 18550560 | Chevrier J, Eskenazi B, Holland N, Bradman A, Barr DB: Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy. Am J Epidemiol. 2008 Aug 1;168(3):298-310. Epub 2008 Jun 10. In this study, the authors' objective was to determine whether serum concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene, p,p'-dichlorodiphenyl trichloroethane (DDT), o,p'-DDT, and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnancy. These compounds, as well as thyroid-stimulating hormone, total and free were measured in serum samples collected between October 1999 and October 2000 from 334 pregnant women living in the Salinas Valley, California. |
2(0,0,0,2) | Details |
| 19182106 | Chiappini F, Alvarez L, Lux-Lantos V, Randi AS, Kleiman de Pisarev DL: Hexachlorobenzene triggers apoptosis in rat thyroid follicular cells. Toxicol Sci. 2009 Apr;108(2):301-10. Epub 2009 Jan 30. The current study demonstrates that only the exposure to the highest HCB dose for 30 days, has adverse effects on thyroid endpoints examined related to thyroid gland morphology, and 3,3'5,5'- (T (4), serum levels, without changes in thyroid-stimulating hormone concentrations or in thyroid gland weight. |
1(0,0,0,1) | Details |
| 19750101 | Dallaire R, Dewailly E, Pereg D, Dery S, Ayotte P: Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environ Health Perspect. 2009 Sep;117(9):1380-6. Epub 2009 May 12. METHODS: We measured thyroid parameters [thyroid-stimulating-hormone (TSH), free (fT (4)), total (tT (3)), and thyroxine-binding globulin (TBG)] and concentrations of 41 contaminants, including PCBs and their metabolites, organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), perfluorooctanesulfonate (PFOS), and a measure of dioxin-like compounds, detected in plasma samples from Inuit adults (n = 623). Moreover, we found negative associations between fT (4) levels and hexachlorobenzene concentrations. |
1(0,0,0,1) | Details |
| 18814871 | Dallaire R, Dewailly E, Ayotte P, Muckle G, Laliberte C, Bruneau S: Effects of prenatal exposure to organochlorines on thyroid hormone status in newborns from two remote coastal regions in Quebec, Canada. Environ Res. 2008 Nov;108(3):387-92. Epub 2008 Sep 23. OBJECTIVES: We investigated the potential impact of transplacental exposure to PCBs and hexachlorobenzene (HCB) on TH concentrations in neonates from two remote coastal populations exposed to OCs through the consumption of seafood products. Lawrence River (n=260) (Quebec, Canada) for thyroid parameters [thyroid-stimulating hormone (TSH), free T4 (fT4), total T3 (tT3), and -binding globuline (TBG)] and contaminants analyses. |
1(0,0,0,1) | Details |
| 18560538 | Schell LM, Gallo MV, Denham M, Ravenscroft J, DeCaprio AP, Carpenter DO: Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youth. Environ Health Perspect. 2008 Jun;116(6):806-13. BACKGROUND: It is well documented that acute exposure to high levels of persistent organic pollutants, such as polychlorinated biphenyls (PCBs), p,p'-dichlorophenyldichloroethylene (p,p'-DDE), and hexachlorobenzene (HCB), can affect human health including thyroid function. OBJECTIVE: We investigated whether levels of PCBs, p,p'-DDE, HCB, mirex, lead, and mercury reflecting past chronic exposure are associated with alterations in levels of thyroid-stimulating hormone (TSH), (T (3)), total (TT (4)), and free (FT (4)) among older children and adolescents. |
1(0,0,0,1) | Details |
| 12762077 | Langer P, Kocan A, Tajtakova M, Petrik J, Chovancova J, Drobna B, Jursa S, Pavuk M, Koska J, Trnovec T, Sebokova E, Klimes I: Possible effects of polychlorinated biphenyls and organochlorinated pesticides on the thyroid after long-term exposure to heavy environmental pollution. J Occup Environ Med. 2003 May;45(5):526-32. Thyroid volume, hypoechogenicity and nodules (by ultrasound), presence of antithyroid peroxidase (anti-TPO) antibodies, and abnormal thyroid-stimulating hormone (TSH) levels in serum (by radioimmunoassay) were examined in 101 adults from the PCB-polluted area in 360 controls. Serum levels of PCBs, hexachlorobenzene, gamma-hexachlorocyclohexane (HCH), p,p'-DDT (1,1,1-trichloro-2,2'-bis (p-chlorophenyl) ethane), and p,p'-DDE (1,1-dichloro-2,2'-bis (p-chlorophenyl) ethene) were measured by high-resolution gas chromatography. |
1(0,0,0,1) | Details |