Protein Information

Name IL 4
Synonyms B cell differentiation factor gamma; B cell growth factor; B cell stimulatory factor 1; BCDF gamma; BCDFg; BCDFgamma; BCGF; BSF 1…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
11119253 Vandebriel RJ, Meredith C, Scott MP, van Dijk M, van Loveren H: Interleukin-10 is an unequivocal Th2 parameter in the rat, whereas interleukin-4 is not. Scand J Immunol. 2000 Nov;52(5):519-24.

Exposure of Wistar rats to the immunotoxic compounds hexachlorobenzene (HCB), bis (tri-n-butyltin) oxide, and benzo (a) pyrene was previously found to affect mRNA expression of interleukin (IL)-2, IL-2R alpha-chain, and interferon (IFN)-gamma, the prototypic Th1 cytokine.
8(0,0,0,8) Details
11266329 Daniel V, Huber W, Bauer K, Suesal C, Conradt C, Opelz G: Associations of blood levels of PCB, HCHS, and HCB with numbers of lymphocyte subpopulations, in vitro lymphocyte response, plasma cytokine levels, and immunoglobulin autoantibodies. Environ Health Perspect. 2001 Feb;109(2):173-8.

Patients with increased PCB 138 (> 710 ng/L) had more frequently undetectable interleukin-4 blood levels than patients with PCB 138 below the mean, and patients with increased PCB 101 (> 31 ng/L) more often had low DR+ cell counts in the blood (< 190/microL) than patients with PCB 101 below the mean.
Pentachlorophenol (PCP), hexachlorocyclohexane-[alpha], -beta, and -[gamma] (HCH-[alpha], -beta, and -[gamma]), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) are widely distributed industrial chemicals.
1(0,0,0,1) Details
9465272 Vandebriel RJ, Meredith C, Scott MP, Roholl PJ, Van Loveren H: Effects of in vivo exposure to bis (tri-n-butyltin) oxide, hexachlorobenzene, and benzo (a) pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels. Toxicol Appl Pharmacol. 1998 Jan;148(1):126-36.

Spleen cells were cultured with Con A and analyzed by dot blot hybridization for IL-2, IFN-gamma, IL-2 receptor alpha-chain (IL-2R alpha; CD25), and IL-4 mRNA levels.
1(0,0,0,1) Details
12696651 Daniel V, Huber W, Bauer K, Suesal C, Conradt C, Opelz G: Associations of dichlorodiphenyltrichloroethane (DDT) 4.4 and dichlorodiphenyldichloroethylene (DDE) 4.4 blood levels with plasma IL-4. Arch Environ Health. 2002 Nov-Dec;57(6):541-7.

Blood levels of DDT, DDE, DDD, 2,3,4,5,6-pentachlorophenol (PCP), polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and gamma-hexachlorocyclohexanes (HCHs) were determined, and blood lymphocyte subpopulations, in vitro responses to mitogens or pooled allogeneic stimulator cells, plasma neopterin, and cytokine and soluble cytokine receptor levels were studied.
3(0,0,0,3) Details