Protein Information

Name CD4
Synonyms CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
14644672 Bilrha H, Roy R, Moreau B, Belles-Isles M, Dewailly E, Ayotte P: In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury. Environ Health Perspect. 2003 Dec;111(16):1952-7.

Cord blood samples were collected for organochlorine and mercury analyses and also to isolate cord blood mononuclear cells (CBMCs) for the in vitro assessment of cytokine production and expression of surface markers after mitogenic stimulation (CD4 (+) CD45RO (+), CD8 (+) CD45RO (+), CD3 (+) CD25 (+), and CD8 (+) HLA-DR (+)).
Blood mercury and plasma concentrations of polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis (4-chlorophenyl) ethylene (p,p'-DDE), and hexachlorobenzene (HCB) were significantly higher in the subsistence fishing group than in the reference group (p < 0.001).
1(0,0,0,1) Details
8567023 Schielen P, Van Rodijnen W, Pieters RH, Seinen W: Hexachlorobenzene treatment increases the number of splenic B-1-like cells and serum autoantibody levels in the rat. Immunology. 1995 Dec;86(4):568-74.

0(0,0,0,0) Details
10207981 Bruder MC, Spanhaak S, Bruijntjes JP, Michielsen CP, Vos JG, Kuper CF: Intestinal T lymphocytes of different rat strains in immunotoxicity. . Toxicol Pathol. 1999 Mar-Apr;27(2):171-9.

The explorative study with the 2 model immunomodulating compounds demonstrated that hexachlorobenzene increased the number of intraepithelial T lymphocytes with CD8+ phenotype at the cost of T cells with CD4+ phenotype in Lewis rats.
6(0,0,1,1) Details