| Name | ferrochelatase |
|---|---|
| Synonyms | EPP; FCE; FECH; Ferrochelatase; Ferrochelatase (protoporphyria); Heme synthase; Heme synthetase; Iron chelatase… |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2744203 | Rios de Molina MC, Taira MC, San Martin de Viale LC: Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. Int J Biochem. 1989;21(2):219-25. The aim of the present work is to shed light on the way of action of hexachlorobenzene (HCB) on hepatic ferrochelatase the mitochondrial enzyme which catalyzes the last step of haem biosynthetic pathway. 2. |
38(0,1,2,3) | Details |
| 1864443 | Rios de Molina MC, Billi de Catabbi S, San Martin de Viale LC: Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. Int J Biochem. 1991;23(7-8):669-73. |
13(0,0,2,3) | Details |
| 6636202 | Miranda CL, Wang JL, Henderson MC, Carpenter HM, Nakaue HS, Buhler DR: Studies on the porphyrinogenic action of 1,2,4-trichlorobenzene in birds. Toxicology. 1983 Sep;28(1-2):83-92. In contrast, ferrochelatase activity was found to be unchanged 1 day after TCB. |
3(0,0,0,3) | Details |
| 6721832 | Wainstok de Calmanovici R, Rios de Molina MC, Taira de Yamasato MC, Tomio JM, San Martin de Viale LC: Mechanism of hexachlorobenzene-induced porphyria in rats. Biochem J. 1984 Mar 15;218(3):753-63. Subsequently, an increase in delta-aminolaevulinate (AmLev) synthase and ferrochelatase was detected; AmLev dehydratase was the last to increase. |
2(0,0,0,2) | Details |
| 12426626 | Rios de Molina MC, Mazzetti MB, Galigniana M, Aldonatti C, Tomio JM, San Martin de Viale LC: The decrease in uroporphyrinogen decarboxylase activity induced by predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage. Braz J Med Biol Res. 2002 Nov;35(11):1273-83. We evaluated the porphyrinogenic ability of (20% in drinking water) per se, its effect on the development of sporadic porphyria cutanea tarda induced by hexachlorobenzene in female Wistar rats (170-190 g, N = 8/group), and the relationship with hepatic damage. reduced the activities of uroporphyrinogen decarboxylase, dehydrase and ferrochelatase. |
1(0,0,0,1) | Details |
| 1781034 | Wainstok de Calmanovici R, Cochon AC, Aldonatti C, Cabral JR, San Martin de Viale LC: Sex comparison of heme pathway in rats bearing hepatic tumors. Tumori. 1991 Oct 31;77(5):379-84. The present study was undertaken to explore the effect of the presence of hepatic tumors induced by diethylinitrosamine (DENA) on the metabolic heme pathway, and to assess whether these tumors can modify the response of rats to the porphyrinogenic drug hexachlorobenzene (HCB) and whether the above mentioned effects occur to a greater extent in females than males. The results obtained showed that: a) Females were more susceptible to the hepatocarcinogenicity of DENA than males. b) Female normal and DENA treated rats were more susceptible than male rats to the porphyrinogenicity of HCB. c) The presence of hepatic DENA induced tumors could diminish basal hepatic ferrochelatase activity. d) Hepatic tumors could modify the response of animals to a porphyrinogenic drug such as HCB. |
1(0,0,0,1) | Details |
| 8998371 | Rios de Molina MC, Iglesias S, Lauria L, San Martin de Viale LC: Precancerous pathology evoked by hexachlorobenzene treatment. Acta Physiol Pharmacol Ther Latinoam. 1996;46(2):71-81. So it was studied, in liver: a) content which was significantly increased at five months of HCB treatment, specially in males, and the pattern of accumulated porphyrins which was altered independent of the sex, b) haem pathway enzymes:delta aminolaevulinic acid synthase, ferrochelatase and porphyrinogen carboxylyase (PCL); among which only PCL appeared to be altered just at ten months of HCB feeding. |
1(0,0,0,1) | Details |