Protein Information

Name interferon gamma
Synonyms IFG; IFI; IFN gamma; IFNG; IFNgamma; Immune interferon; Interferon gamma; Interferon gamma precursor…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
11119253 Vandebriel RJ, Meredith C, Scott MP, van Dijk M, van Loveren H: Interleukin-10 is an unequivocal Th2 parameter in the rat, whereas interleukin-4 is not. Scand J Immunol. 2000 Nov;52(5):519-24.

Exposure of Wistar rats to the immunotoxic compounds hexachlorobenzene (HCB), bis (tri-n-butyltin) oxide, and benzo (a) pyrene was previously found to affect mRNA expression of interleukin (IL)-2, IL-2R alpha-chain, and interferon (IFN)-gamma, the prototypic Th1 cytokine.
6(0,0,1,1) Details
12696651 Daniel V, Huber W, Bauer K, Suesal C, Conradt C, Opelz G: Associations of dichlorodiphenyltrichloroethane (DDT) 4.4 and dichlorodiphenyldichloroethylene (DDE) 4.4 blood levels with plasma IL-4. Arch Environ Health. 2002 Nov-Dec;57(6):541-7.

Blood levels of DDT, DDE, DDD, 2,3,4,5,6-pentachlorophenol (PCP), polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and gamma-hexachlorocyclohexanes (HCHs) were determined, and blood lymphocyte subpopulations, in vitro responses to mitogens or pooled allogeneic stimulator cells, plasma neopterin, and cytokine and soluble cytokine receptor levels were studied.
The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4.
1(0,0,0,1) Details