| Name | aldehyde dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | aldehyde dehydrogenase; aldehyde dehydrogenases |
| Name | molinate |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14967014 | Zimmerman LJ, Valentine HL, Valentine WM: Characterization of S-(N,N-Dialkylaminocarbonyl) Adducts and Enzyme Inhibition Produced by Thiocarbamate Herbicides in the Rat. Chem Res Toxicol. 2004 Feb;17(2):258-67. Molinate has been shown to generate an S-hexahydro-1H-azepine-1-carbonyl adduct on the Cys-125 residue of the beta2- and beta3-chains of rat globin analogous to that reported for disulfiram and to inhibit aldehyde dehydrogenase and nonspecific esterase activity. |
31(0,1,1,1) | Details |
| 7968224 | Quistad GB, Sparks SE, Casida JE: Aldehyde dehydrogenase of mice inhibited by thiocarbamate herbicides. Life Sci. 1994;55(20):1537-44. The in vivo effects of other thiocarbamate herbicides at 8 mg/kg on ALDH activity and 40 mg/kg on levels decrease in the order of thiobencarb, pebulate, vernolate and molinate > butylate and triallate >> cycloate. |
2(0,0,0,2) | Details |
| 7840792 | Hart BW, Faiman MD: Inhibition of rat liver low Km aldehyde dehydrogenase by thiocarbamate herbicides. Biochem Pharmacol. 1995 Jan 18;49(2):157-63. Representative herbicides studied were n-propyl, n-propylthiocarbamate ethyl ester (EPTC), molinate, vernolate, ethiolate and butylate. |
2(0,0,0,2) | Details |
| 8605289 | Staub RE, Sparks SE, Quistad GB, Casida JE: S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors. Chem Res Toxicol. 1995 Dec;8(8):1063-9. Eight S-alkyl and S-(chloroallyl) thiocarbamate herbicides (EPTC, molinate, butylate, vernolate, pebulate, diallate, sulfallate, and triallate), but not their S-chlorobenzyl analog (thiobencarb), undergo sequential liberation of the thiocarbamic acid and then S-methylation, forming the S-methyl thiocarbamates which are new metabolites and potential aldehyde dehydrogenase inhibitors. |
2(0,0,0,2) | Details |