| Name | CYP3A |
|---|---|
| Synonyms | CP33; CYP3; HLP; CYP3A; CP34; CYP 3A4; CYP 3; CYP3A3… |
| Name | myclobutanil |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19409404 | Goetz AK, Dix DJ: Toxicogenomic effects common to triazole antifungals and conserved between rats and humans. Toxicol Appl Pharmacol. 2009 Jul 1;238(1):80-9. Epub 2009 May 3. The triazole antifungals myclobutanil, propiconazole and triadimefon cause varying degrees of hepatic toxicity and disrupt steroid hormone homeostasis in rodent in vivo models. Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1. |
1(0,0,0,1) | Details |
| 17484520 | Sun G, Grindstaff RD, Thai SF, Lambert GR, Tully DB, Dix DJ, Nesnow S: Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon. Xenobiotica. 2007 Feb;37(2):180-93. These results indicate that triadimefon and myclobutanil, like other triazole-containing conazoles, induced CYP2B and CYP3A families of cytochromes in rat liver. |
6(0,0,1,1) | Details |
| 16971344 | Barton HA, Tang J, Sey YM, Stanko JP, Murrell RN, Rockett JC, Dix DJ: Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomes. Xenobiotica. 2006 Sep;36(9):793-806. Human and rat CYP2C and CYP3A enzymes were the most active. |
1(0,0,0,1) | Details |