Protein Information

Name angiotensin II
Synonyms AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8…

Compound Information

Name piperazine
CAS piperazine

Reference List

PubMed Abstract RScore(About this table)
11780430 Yang X, Hui J, Jiang W: Angiotensin II type 1 receptor modulation of L-type calcium currents in guinea-pig ventricular cells. Chin Med J. 2001 Jun;114(6):577-82.

OBJECTIVE: To study the cellular mechanism of the effect of Ang II on ICa,L in single guinea-pig ventricular cells by using losartan and 1-(5-lsoquinolinylsulfonyl)-2-Methyl-Piperazine (H-7) as the Ang II type 1 receptor (AT1) inhibitor and protein kinase C inhibitor, respectively.
35(0,1,1,5) Details
15072840 Moloney GP, Garavelas A, Martin GR, Maxwell M, Glen RC: Synthesis and serotonergic activity of variously substituted (3-amido) phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor. Eur J Med Chem. 2004 Apr;39(4):305-21.

From the 3-amidophenyl-piperazine series, N-(4-(4-chlorophenyl) thiazol-2-yl-3-(4-methyl-1-piperazinyl) benzamide (30) and from the benzo [b] thiophene-4-piperazine series N-(2-ethylphenyl)-4-(4-methyl-1- piperazinyl)-1-benzo [b] thiophene-2-carboxamide (38) were identified as a highly potent, silent (as judged by the inability of angiotensin II to unmask 5-HT (1B) receptor mediated agonist activity in the rabbit femoral artery) and competitive vascular 5-HT (1B) receptor antagonist.
31(0,1,1,1) Details
15869747 Voigt JP, Hortnagl H, Rex A, van Hove L, Bader M, Fink H: Brain angiotensin and anxiety-related behavior: the transgenic rat TGR (ASrAOGEN) 680. Brain Res. 2005 Jun 7;1046(1-2):145-56.


The transgenic rat TGR (ASrAOGEN) 680, characterized by a transgene-producing antisense RNA against angiotensinogen in the brain, provides an opportunity to study the behavioral effects of angiotensin.
2(0,0,0,2) Details