| Name | alpha 2C adrenoceptors |
|---|---|
| Synonyms | ADRA2C; ADRA2L2; ADRA2RL2; ADRARL 2; ADRARL2; ALPHA2CAR; Alpha 2C adrenergic receptor; Alpha 2C adrenoceptor… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11226402 | Rizzo CA, Ruck LM, Corboz MR, Umland SP, Wan Y, Shah H, Jakway J, Cheng L, McCormick K, Egan RW, Hey JA: Postjunctional alpha (2C)-adrenoceptor contractility in human saphenous vein. Eur J Pharmacol. 2001 Feb 16;413(2-3):263-9. BHT-920-induced contractions were inhibited by the alpha (2)-adrenoceptor antagonist yohimbine (17--yohimban-16-carboxylic acid methyl ester hydrochloride; pA (2)=8.7+/-0.5), but not by the alpha (1)-adrenoceptor antagonist prazosin (1-[4-Amino-6,7-dimethoxy-2-quinazolinyl]-4-[2-furanylcarbonyl]-piperazine hydrochloride; 300 nM). |
3(0,0,0,3) | Details |
| 11137626 | Taoda M, Adachi YU, Uchihashi Y, Watanabe K, Satoh T, Vizi ES: Effect of dexmedetomidine on the release of [3H]- from rat kidney cortex slices: characterization of alpha2-adrenoceptor. Neurochem Int. 2001 Apr;38(4):317-22. In contrast, ARC-239 (2-(2,4-(o-piperazine-1-yl)-ethyl-4,4-dimethyl-1,3-(2H, 4H) disoguinolinedione a selective alpha (2B)-antagonist, had no effect on the release and failed to prevent the effect of dexmedetomidine. |
0(0,0,0,0) | Details |
| 17034141 | Hoglund IP, Silver S, Engstrom MT, Salo H, Tauber A, Kyyronen HK, Saarenketo P, Hoffren AM, Kokko K, Pohjanoksa K, Sallinen J, Savola JM, Wurster S, Kallatsa OA: Structure-activity relationship of quinoline derivatives as potent and selective alpha (2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. The 3-position on the piperazine ring was also found to play an appreciable role, as substitutions in that position exerted a significant and stereospecific beneficial effect on the alpha (2C)-adrenoceptor affinity and potency. |
34(0,1,1,4) | Details |