Protein Information

Name aldehyde dehydrogenase (protein family or complex)
Synonyms aldehyde dehydrogenase; aldehyde dehydrogenases

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
4347965 Bayly RC, Wigmore GJ: Metabolism of phenol and cresols by mutants of Pseudomonas putida. J Bacteriol. 1973 Mar;113(3):1112-20.

This strain was used to show that the products of meta ring fission of the cresols and phenol are metabolized as follows: (i) ortho- and meta-cresol exclusively by a hydrolase; (ii) para-cresol exclusively by a NAD (+)-dependent aldehyde dehydrogenase; (iii) phenol by both a NAD (+)-dependent dehydrogenase and a hydrolase in the approximate ratio of 5 to 1.
32(0,1,1,2) Details
8579380 Kawamoto T, Koga M, Oyama T, Kodama Y: Habitual and genetic factors that affect urinary background levels of biomarkers for organic solvent exposure. Arch Environ Contam Toxicol. 1996 Jan;30(1):114-20.


The genotypes of five metabolizing enzymes, that is, low Km aldehyde dehydrogenase (ALDH2), polymorphic N-acetyl transferase (NAT2), cytochrome P-4501A1 (CYP1A1), cytochrome P-4502E1 (CYP2E1), and glutathione-S-transferase mu (GSTM1) were determined form peripheral blood samples.
1(0,0,0,1) Details
6853447 Hughes EJ, Bayly RC: Control of catechol meta-cleavage pathway in Alcaligenes eutrophus. J Bacteriol. 1983 Jun;154(3):1363-70.


Studies with a putative polarity mutant defective in the expression of aldehyde dehydrogenase suggested that the structural genes encoding this and subsequent enzymes of the pathway exist in the same operon.
1(0,0,0,1) Details
10565539 Cronin CN, Kim J, Fuller JH, Zhang X, McIntire WS: Organization and sequences of p-hydroxybenzaldehyde dehydrogenase and other plasmid-encoded genes for early enzymes of the p-cresol degradative pathway in Pseudomonas putida NCIMB 9866 and 9869. DNA Seq. 1999;10(1):7-17.


The gene (designated pchA) encoding the aldehyde dehydrogenase that is required to metabolise the p-hydroxybenzaldehyde produced by the degradation of p-cresol in Pseudomonas putida NCIMB 9866 and 9869 has been identified on plasmids pRA4000 and pRA500, respectively.
1(0,0,0,1) Details
2194577 Nordlund I, Shingler V: Nucleotide sequences of the meta-cleavage pathway enzymes 2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic semialdehyde hydrolase from Pseudomonas CF600. Biochim Biophys Acta. 1990 Jun 21;1049(2):227-30.


HMSD has homology with a number of aldehyde dehydrogenases from various eukaryotic sources.
1(0,0,0,1) Details
7849865 Kawamoto T, Murata K, Koga M, Hattori Y, Kodama Y: Distribution of urinary hippuric acid concentrations by ALDH2 genotype. Occup Environ Med. 1994 Dec;51(12):817-21.


OBJECTIVES--To clarify the relation between the genetic polymorphism of ALDH2 (low Km aldehyde dehydrogenase) and toluene metabolism.
1(0,0,0,1) Details