Protein Information

Name FKBP12.6
Synonyms 12.6 kDa FKBP; PPIase; Rotamase; Calstabin 2; FK506 binding protein 1 like; FK506 binding protein 12.6; FK506 binding protein 1B; FK506 binding protein 1B (12.6 kD)…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
12443530 George CH, Sorathia R, Bertrand BM, Lai FA: In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. Biochem J. 2003 Mar 1;370(Pt 2):579-89.

However, in CHO (hRyR2) cells co-expressing FKBP12.6, Ca (2+) release triggered by the addition of 4-chloro- m -cresol was markedly decreased.
86(1,1,1,6) Details
12919952 George CH, Higgs GV, Lai FA: Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circ Res. 2003 Sep 19;93(6):531-40. Epub 2003 Aug 14.


Furthermore, equivalent interaction between mutant and WT hRyR2 and FKBP12.6 was demonstrated.
1(0,0,0,1) Details