Protein Information

Name azoreductase
Synonyms Diaphorase; DHQU; DIA 4; DIA4; DT diaphorase; DTD; Diaphorase (NADH/NADPH); Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
9145445 Ballongue J, Schumann C, Quignon P: Effects of lactulose and lactitol on colonic microflora and enzymatic activity. Scand J Gastroenterol Suppl. 1997;222:41-4.

These variations in colonic flora had the following consequences: (i) a reduced activity of pro-carcinogenic enzymes: azoreductase, 7 alpha-dehydroxylase, beta-glucuronidase, nitroreductase and urease activity; (ii) a global increase of short-chain fatty acids in faeces; (iii) an effect on pH and moisture of faeces, and (iv) also on aromatic compounds such as phenol, cresol, indole and skatol.
31(0,1,1,1) Details
1657742 Fujiwara S, Hirota T, Nakazato H, Muzutani T, Mitsuoka T: Effect of Konjac mannan on intestinal microbial metabolism in mice bearing human flora and in conventional F344 rats. Food Chem Toxicol. 1991 Sep;29(9):601-6.


Dietary KM led to a significant reduction in faecal beta-glucuronidase, nitroreductase and azoreductase activities, and in the production of phenol and indole in the faeces of conventional F344 rats.
1(0,0,0,1) Details
493719 Savolainen H: Toxic effects of peroral o-cresol intake on rat brain. . Res Commun Chem Pathol Pharmacol. 1979 Aug;25(2):357-64.


The biochemical effects in the cerebral homogenate were inconspicuous, and they included increased RNA content initially, and reduced glutathione concentration and azoreductase activity at the end of experiment.
1(0,0,0,1) Details