| Name | I100 |
|---|---|
| Synonyms | 100 kDa ileum brush border membrane protein; 100 kDa ileum bush border membrane protein; I100; Ileal dipeptidylpeptidase; N acetylated alpha linked acidic dipeptidase like protein; N acetylated alpha linked acidic dipeptidase like 1; NAALADASEL; NAALADL… |
| Name | cresol |
|---|---|
| CAS | methylphenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15329936 | Fishman A, Tao Y, Bentley WE, Wood TK: Protein engineering of toluene 4-monooxygenase of Pseudomonas mendocina KR1 for synthesizing 4-nitrocatechol from nitrobenzene. Biotechnol Bioeng. 2004 Sep 20;87(6):779-90. It was believed that position I100 of the alpha subunit of the hydroxylase (TmoA) is the most significant for the change in substrate reactivity due to previous results in our lab with a similar enzyme, toluene ortho-monooxygenase of Burkholderia cepacia G4. |
2(0,0,0,2) | Details |
| 15607233 | Vardar G, Ryu K, Wood TK: Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for oxidizing nitrobenzene to 3-nitrocatechol, 4-nitrocatechol, and nitrohydroquinone. J Biotechnol. 2005 Jan 26;115(2):145-56. To increase the oxidation rate and alter the oxidation regiospecificity of nitro aromatics as well as to study the role of the active site residues I100, Q141, T201, and F205 of the alpha hydroxylase fragment of ToMO (TouA), DNA shuffling and saturation mutagenesis were used to generate random mutants. |
1(0,0,0,1) | Details |
| 15184119 | Vardar G, Wood TK: Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for synthesizing 4-methylresorcinol, methylhydroquinone, and pyrogallol. Appl Environ Microbiol. 2004 Jun;70(6):3253-62. To synthesize novel dihydroxy and trihydroxy derivatives of and toluene, DNA shuffling of the alpha-hydroxylase fragment of ToMO (TouA) and saturation mutagenesis of the TouA active site residues I100, Q141, T201, and F205 were used to generate random mutants. |
1(0,0,0,1) | Details |
| 15231803 | Tao Y, Fishman A, Bentley WE, Wood TK: Altering toluene 4-monooxygenase by active-site engineering for the synthesis of 3-methoxycatechol, methoxyhydroquinone, and methylhydroquinone. J Bacteriol. 2004 Jul;186(14):4705-13. After these new reactions were discovered, saturation mutagenesis was performed near the diiron catalytic center at positions I100, G103, and A107 of the alpha subunit of the hydroxylase (TmoA) based on directed evolution of the related toluene o-monooxygenase of Burkholderia cepacia G4 (K. |
1(0,0,0,1) | Details |