| Name | ubiquitin |
|---|---|
| Synonyms | HMG20; RPS27A; UBA80; UBCEP 1; UBCEP1; UBA52; UBCEP 2; UBCEP2… |
| Name | griseofulvin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2462130 | Ohta M, Marceau N, Perry G, Manetto V, Gambetti P, Autilio-Gambetti L, Metuzals J, Kawahara H, Cadrin M, French SW: Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes. Lab Invest. 1988 Dec;59(6):848-56. To investigate the relationship of cytokeratin intermediate filaments (IFs) and Mallory bodies (MBs) to the regulatory protein ubiquitin, the griseofulvin-fed mouse was examined by double-label immunocytochemistry. |
18(0,0,2,8) | Details |
| 8781332 | Yuan QX, Marceau N, French BA, Fu P, French SW: Mallory body induction in drug-primed mouse liver. . Hepatology. 1996 Sep;24(3):603-12. The MBs were heavily ubiquitinated and were associated with increased ubiquitin-protein conjugates as indicated by Western blotting, suggesting that ubiquitinization of cytokeratin protein are involved in the formation of MB aggregation. A model was developed where MB formation was induced by refeeding either of the drugs griseofulvin or diethyl 1,4-dihydro-1,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC). |
1(0,0,0,1) | Details |
| 12388748 | Nakamichi I, Hatakeyama S, Nakayama KI: Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. Mol Biol Cell. 2002 Oct;13(10):3441-51. Mice fed long term with griseofulvin are an animal model of MB formation. Overexpression of K18 in HepG2, HeLa, or COS-7 cells also induced the formation of intracellular aggregates that stained with antibodies to ubiquitin and with rhodamine B (characteristics of MBs formed in vivo), eventually leading to cell death. |
1(0,0,0,1) | Details |
| 16729998 | Roomi MW, Gaal K, Yuan QX, French BA, Fu P, Bardag-Gorce F, French SW: Preneoplastic liver cell foci expansion induced by thioacetamide toxicity in drug-primed mice. Exp Mol Pathol. 2006 Aug;81(1):8-14. Epub 2006 May 24. Mice primed by feeding griseofulvin or diethyl 1,4-dihydro 1,4,6-trimethyl 3,5- decarboxylate for 5 months followed by drug withdrawal for 1 month (drug-primed mice) were given thioacetamide intraperitoneally, and the livers were subsequently studied at intervals up to 7 days. Mallory bodies were identified by immunoperoxidase stains for ubiquitin and cytokeratin. |
1(0,0,0,1) | Details |
| 18443813 | Strnad P, Stumptner C, Zatloukal K, Denk H: Intermediate filament cytoskeleton of the liver in health and disease. Histochem Cell Biol. 2008 Jun;129(6):735-49. Epub 2008 Apr 29. MDBs are found in various liver diseases including alcoholic and non-alcoholic steatohepatitis and can be formed in mice by feeding hepatotoxic substances griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). MDBs also arise in cell culture after transfection with K8/K18, ubiquitin, and p62. |
1(0,0,0,1) | Details |
| 8759055 | Yuan QX, Marceau N, French BA, Fu P, French SW: Heat shock in vivo induces Mallory body formation in drug primed mouse liver. Exp Mol Pathol. 1995 Aug;63(1):63-76. We speculate that this role is through the protein unfolding function of HSP, which leads to the aggregation of the cytokeratins to form MBs as well as to polyubiquitin binding to these proteins in a manner analogous to amyloid formation. Mice were primed by a 5-month feeding of griseofulvin (GF) or diethyl 1,4-dehydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) followed by drug withdrawal for 1 month. |
1(0,0,0,1) | Details |
| 17531973 | Zatloukal K, French SW, Stumptner C, Strnad P, Harada M, Toivola DM, Cadrin M, Omary MB: From Mallory to Mallory-Denk bodies: what, how and why? . Exp Cell Res. 2007 Jun 10;313(10):2033-49. Epub 2007 Apr 27. Helmut Denk and colleagues described the first animal model of MBs in 1975 that involves feeding mice griseofulvin. The major constituents of MDBs include keratins 8 and 18 (K8/18), ubiquitin, and p62. |
1(0,0,0,1) | Details |