| 15236455 |
Balakrishnan A, Rege BD, Amidon GL, Polli JE: Surfactant-mediated dissolution: contributions of solubility enhancement and relatively low micelle diffusivity. J Pharm Sci. 2004 Aug;93(8):2064-75.
The following model was derived to predict the degree to which surfactants enhance griseofulvin dissolution: phi = 1 + (fm/ff).((D (D-M) 2/3)/(DD2/3)) where phi is the degree of surfactant-mediated dissolution enhancement, fm is the fraction of the drug in micelle, and ff is the fraction of free drug, and DD and D (D-M) are the diffusivities of free drug and drug-loaded micelles, respectively. |
31(0,1,1,1) |
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