Protein Information

Name CS2
Synonyms Alcagamma; CLSTN 2; CLSTN2; CS2; CSTN 2; CSTN2; Calsyntenin 2; Calsyntenin 2 precursor…

Compound Information

Name thiram
CAS

Reference List

PubMed Abstract RScore(About this table)
869529 Odeyemi O, Alexander M: Resistance of Rhizobium strains to phygon, spergon, and thiram. . Appl Environ Microbiol. 1977 Apr;33(4):784-90.

Resting cells of thiram-metabolizing R. meliloti formed large quantities of dimethyldithiocarbamate, dimethylamine, and CS2 from the pesticide.
82(1,1,1,2) Details
11227421 Heise S, Weber H, Alder L: Reasons for the decomposition of the fungicide thiram during preparation of fruit and vegetable samples and consequences for residue analysis. Fresenius J Anal Chem. 2000 Apr;366(8):851-6.

For the screening of thiram residues, the often used Keppel method, which determines CS2 from thiram or dithiocarbamates seems to be applicable even if samples had been coarsely cut, since decomposition of the CS2-forming intermediates is slower than the breakdown of thiram itself.
81(1,1,1,1) Details
8171915 Schwack W, Nyanzi S: Analysis of dithiocarbamate fungicides. Z Lebensm Unters Forsch. 1994 Jan;198(1):3-7.

Second-derivative UV-spectroscopic determination of CS2, COS, and thiram (TMTD)..
34(0,1,1,4) Details
3953292 Dalvi RR, Deoras DP: Metabolism of a dithiocarbamate fungicide thiram to carbon disulfide in the rat and its hepatotoxic implications. Acta Pharmacol Toxicol. 1986 Jan;58(1):38-42.

The data confirm that CS2 is an in vivo metabolite of thiram and may be, in part, responsible for the observed hepatotoxicity.
125(1,2,4,5) Details
8171921 Schwack W, Nyanzi S: Analysis of dithiocarbamate fungicides. Z Lebensm Unters Forsch. 1994 Jan;198(1):8-10.

The acid hydrolysis products (CS2, COS, and H2S) of thiram (tetramethylthiram disulphide, TMTD) absorbed in a methanolic amine reagent (ethylenediamine, piperidine) were investigated by second derivative UV spectroscopy.
32(0,1,1,2) Details
12564678 Coldwell MR, Pengelly I, Rimmer DA: Determination of dithiocarbamate pesticides in occupational hygiene sampling devices using the isooctane method and comparison with an automatic thermal desorption (ATD) method. J Chromatogr A. 2003 Jan 10;984(1):81-8.

Dithiocarbamate spiked occupational hygiene sampling devices, consisting of glass fibre (GF/A) filters, cotton pads, cotton gloves and disposable overalls, were reduced under acidic conditions and the CS2 evolved as a decomposition product was extracted into isooctane.
Thiram spiked GF/A filters gave an average recovery of 107% with an RSD of 4%.
3(0,0,0,3) Details
7184939 Freundt KJ, Romer KG, Kamal AM: The inhibitory action of dithiocarbamates and carbon disulphide on malondialdehyde formation resulting from lipid peroxidation in rat liver microsomes. J Appl Toxicol. 1981 Aug;1(4):215-9.

The dithiocarbamates (DTCs) disulfiram, thiram, diethyldithiocarbamate and dimethyldithiocarbamate on the equimolar base inhibited to the same extent both the lipid peroxidation (LPO) induced by ascorbic acid (non-enzymatic) and that stimulated by an NADPH-regenerating system with CCl4 admixture (enzymatic).
Carbon disulphide (CS2) inhibited the enzymatic and non-enzymatic stimulated microsomal LPO by 4 orders less than the DTCs.
2(0,0,0,2) Details