| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | thiram |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12458634 | Dalvi PS, Wilder-Ofie T, Mares B, Lane C, Dalvi RR, Billups LH: Effect of cytochrome P450 inducers on the metabolism and toxicity of thiram in rats. Vet Hum Toxicol. 2002 Dec;44(6):331-3. |
162(2,2,2,2) | Details |
| 6520339 | Dalvi RR, Robbins TJ, Williams MK, Deoras DP, Donastorg F, Banks C: Thiram-induced toxic liver injury in male Sprague-Dawley rats. J Environ Sci Health B. 1984 Nov-Dec;19(8-9):703-12. Additional evidence for thiram-induced liver toxicity is provided by the observation that there was approximately 50% inhibition of the activity of hepatic microsomal benzphetamine N-demethylase with a concomitant decrease in the concentration of cytochrome P-450, an important component of the mixed-function oxidase system. |
31(0,1,1,1) | Details |
| 7288902 | Leyck S, Freundt KJ: Thiram-induced disturbance of microsomal phospholipid bioformation and phospholipid fatty acid pattern. J Toxicol Environ Health. 1981 Mar-Apr;7(3-4):533-45. In rats, a single oral dose of 30 mg or 1 g thiram per kilogram produced a significant prolongation of the hexobarbital sleeping time or zoxazolamine paralysis time, respectively, a depression of hepatic microsomal O-demethylation of p-nitroanisole to and a decrease in the microsomal cytochrome P-450 content. |
31(0,1,1,1) | Details |
| 8382714 | Gupta M, Amma MK: Alterations in hepatic biochemistry of mice intoxicated with MIC, carbaryl and thiram. J Appl Toxicol. 1993 Jan-Feb;13(1):33-7. The 1/4 LD50 dose of thiram decreased the cytochrome P-450 content below the control level (69.62%) in 0.75 h and the same dose of MIC could decrease the cytochrome P-450 level by 40% compared to the control after 3 days of consecutive injection. |
7(0,0,1,2) | Details |
| 3953292 | Dalvi RR, Deoras DP: Metabolism of a dithiocarbamate fungicide thiram to carbon disulfide in the rat and its hepatotoxic implications. Acta Pharmacol Toxicol. 1986 Jan;58(1):38-42. Furthermore, measurement of the activities of hepatic microsomal and serum enzymes at 5 hrs and 24 hrs following thiram treatment indicated that thiram caused significant loss of cytochrome P-450 and benzphetamine N-demethylase activity only at 24 hrs interval whereas there was significant elevation of sorbitol dehydrogenase (SDH) and serum glutamic oxalacetic transaminase (SGOT) activity at 5 and 24 hrs after treatment. |
6(0,0,1,1) | Details |
| 11673071 | Rahden-Staron I, Czeczot H, Szumilo M: Induction of rat liver cytochrome P450 isoenzymes CYP 1A and CYP 2B by different fungicides, nitrofurans, and Mutat Res. 2001 Nov 15;498(1-2):57-66. We studied induction of the CYP 1A or CYP 2B monooxygenases in rat liver by the fungicides: thiram, captan, captafol, dodine and the drugs: nitrofurazone, furazolidone and the plant |
2(0,0,0,2) | Details |
| 16190021 | Bebe FN, Panemangalore M: Pesticides and essential minerals modify endogenous antioxidants and cytochrome P450 in tissues of rats. J Environ Sci Health B. 2005;40(5):769-84. In both experiments, six rats/group were fed diets based on the AIN-93M diet (Control) or the same modified to contain either 500 mg (Low Ca), 7 mg Zn (Low Zn): 2 mg (Low Cu), 60 mg zinc (High Zn) or 12 mg (High Cu) in the following combination: Control, LCa/LZn, LCa/LZn/LCu, or HZn/HCu, with and without a pesticide mixture containing acephate, endosulfan, and thiram at 25% LD50 for four or two weeks. |
2(0,0,0,2) | Details |
| 7184939 | Freundt KJ, Romer KG, Kamal AM: The inhibitory action of dithiocarbamates and carbon disulphide on malondialdehyde formation resulting from lipid peroxidation in rat liver microsomes. J Appl Toxicol. 1981 Aug;1(4):215-9. The dithiocarbamates (DTCs) disulfiram, thiram, diethyldithiocarbamate and dimethyldithiocarbamate on the equimolar base inhibited to the same extent both the lipid peroxidation (LPO) induced by (non-enzymatic) and that stimulated by an -regenerating system with CCl4 admixture (enzymatic). In parallel with the inhibition of MDA formation, oxidative destruction of microsomal cytochrome P-450 was delayed with increasing concentrations of the DTCs. |
1(0,0,0,1) | Details |
| 6373031 | Rannug A, Rannug U: Enzyme inhibition as a possible mechanism of the mutagenicity of dithiocarbamic acid derivatives in Salmonella typhimurium. Chem Biol Interact. 1984 May;49(3):329-40. A further enhancement of the radical content of the cells by adding microsomes that produce radicals via autoxidation of cytochrome P-450 is proposed as the mechanism for the 'metabolic activation of TMTD '. |
1(0,0,0,1) | Details |