| 18065196 |
Akgul Y, Derk RC, Meighan T, Rao KM, Murono EP: The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells. Reprod Toxicol. 2008 Jan;25(1):67-75. Epub 2007 Oct 25.
Of interest, estradiol, xenoestrogens (bisphenol-A or 4-tert-octylphenol), a pure antiestrogen (ICI 182,780), or antiandrogens (4-hydroxyflutamide or the vinclozolin metabolite M-2), had no effect on progesterone production even at 1000nM. |
4(0,0,0,4) |
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| 14967917 |
Kubota K, Ohsako S, Kurosawa S, Takeda K, Qing W, Sakaue M, Kawakami T, Ishimura R, Tohyama C: Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat. J Reprod Dev. 2003 Oct;49(5):403-12.
Immunohistochemistry demonstrated intense staining of P450scc in the interstitial cells of VCZ-treated testis on D8. |
1(0,0,0,1) |
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