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O'Connor JC, Frame SR, Ladics GS: Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens. Toxicol Sci. 2002 Sep;69(1):92-108.
The endpoints evaluated included final body and organ weights (liver, thyroid gland, testes, epididymides, prostate, seminal vesicles with fluid, accessory sex gland unit [ASG]), serum hormone concentrations (testosterone [T], estradiol [E2], dihydrotestosterone [DHT], luteinizing hormone [LH], follicle stimulating hormone [FSH], prolactin [PRL], T (3), T (4), and thyroid stimulating hormone [TSH]), and histopathology of the testis, epididymis, and thyroid gland; positive results for each endpoint are described below. |
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Shin JH, Moon HJ, Kim TS, Kang IH, Ki HY, Choi KS, Han SY: Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. Arch Toxicol. 2006 Sep;80(9):547-54. Epub 2006 Feb 18.
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