| 8678907 |
di Ilio C, Sacchetta P, Angelucci S, Bucciarelli T, Pennelli A, Mazzetti AP, Lo Bello M, Aceto A: Interaction of glutathione transferase P1-1 with captan and captafol. . Biochem Pharmacol. 1996 Jul 12;52(1):43-8.
That the inactivation of GSTP1-1 by captan and captafol involves the formation of disulfide bonds between the four cysteinil groups of the enzymes was confirmed by the SDS-PAGE experiments on nondenaturant conditions. |
87(1,1,2,2) |
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| 7683635 |
Tsuda H, Matsumoto K, Ogino H, Ito M, Hirono I, Nagao M, Sato K, Cabral R, Bartsch H: Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens. Jpn J Cancer Res. 1993 Mar;84(3):230-6.
In experiment 1, group 1 animals were initially subjected to partial hepatectomy (PH) 12 h before administration of diethylnitrosamine, 2-amino-3-methylimidazo [4,5-f]-quinoline (IQ), captafol, alpha-hexachlorocyclohexane or diethylstilbestrol (DES), then 2 weeks later underwent a promotion procedure comprising administration of phenobarbital (0.05% in diet) for 8 weeks and D-galactosamine (300 mg/kg, i.g.) at week 3. |
1(0,0,0,1) |
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