Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name potassium thiocyanate
CAS potassium thiocyanate

Reference List

PubMed Abstract RScore(About this table)
11599430 Bobrovnik SA, Margitich VM, Klimashevskii VM, Artamonov MV, Gulaia NM: [Relationship between polyreactive properties of immunoglobulins and level of lipids in them]. Ukr Biokhim Zh. 2001 Jan-Feb;73(1):65-72.

4(0,0,0,4) Details
7237264 Bhasin JL, Lapointe-Shaw L: Antigenic analysis if Pasteurella multocida (serotype 1) by crossed immunoelectrophoresis: characterization of whole cell associated antigens. Can J Microbiol. 1980 Dec;26(12):1392-402.

The reactions of these cellular fractions in crossed immunoelectrophoresis, with reference anti-whole cell immunoglobulins disclosed five antigens in the capsular extract, seven in the potassium thiocyanate extract, one to three in the lipopolysaccharide, three in the heat-stable antigens, and five in the free endotoxin.
6(0,0,1,1) Details
17494322 Gordienko AI, Khimich NV: [Interaction of chaotropically modified immunoglobulins with protein and glicolipid antigens]. Ukr Biokhim Zh. 2006 Nov-Dec;78(6):78-85.

3(0,0,0,3) Details
3693546 Lu YS, Pakes SP, Massey L: Hyperimmune serum from rabbits immunized with potassium thiocyanate extract of Pasteurella multocida protects against homologous challenge. J Clin Microbiol. 1987 Nov;25(11):2173-80.

The results showed that the hyperimmune serum had a very high titer of immunoglobulin G ELISA antibody and a negligible immunoglobulin A ELISA antibody, precipitated 10 different outer membrane protein antigens by radioimmunoprecipitation, and reacted to 10 different membrane vesicle antigens of P. multocida by immunoblotting analysis.
2(0,0,0,2) Details
1163549 Bolton WK, Sande MA, Normansell DE, Sturgill BC, Westervelt FB Jr: Ventriculojugular shunt nephritis with Corynebacterium bovis. Am J Med. 1975 Sep;59(3):417-23.

Immunofluorescent examination of the biopsy specimen demonstrated 2+ granular glomerular basement membrane deposits of immunoglobulin M (IgM), with trace third component of complement (C-3), fourth component of complement (C-4) and immunoglobulin G (IgG).
Potassium thiocyanate microelution of sections prior to examination markedly diminished staining with antihuman antiserum, but did not affect staining with rabbit antiserum.
1(0,0,0,1) Details
3679540 Lu YS, Pakes SP, Massey L, Stefanu C: A potassium thiocyanate extract vaccine prepared from Pasteurella multocida 3:A protects rabbits against homologous challenge. Infect Immun. 1987 Dec;55(12):2967-76.

Rabbits vaccinated with the extract by the i.n. route developed persisting serum immunoglobulin G (IgG) and nasal IgA antibodies, whereas rabbits immunized by the i.m. route produced persisting serum IgG and transient nasal IgA antibodies.
1(0,0,0,1) Details
6372970 Cho HJ, Bohac JG, Yates WD, Bielefeldt Ohmann H: Anticytotoxin activity of bovine sera and body fluids against Pasteurella haemolytica A1 cytotoxin. Can J Comp Med. 1984 Apr;48(2):151-5.

The antibody nature of the cytotoxin neutralizing activity was demonstrated by its neutralization with bovine immunoglobulin G2 purified from pooled seropositive sera.
Sera from a group of cattle which were vaccinated with a potassium thiocyanate extract of P. haemolytica, but which subsequently developed fibrinous pneumonia after aerosol challenge with bovine herpesvirus 1 and P. haemolytica, had significantly lower anticytotoxin activity than sera from another group of cattle which did not develop the disease after similar vaccination and challenge.
1(0,0,0,1) Details
4030090 Ringler DH, Peter GK, Chrisp CE, Keren DF: Protection of rabbits against experimental pasteurellosis by vaccination with a potassium thiocyanate extract of Pasteurella multocida. Infect Immun. 1985 Sep;49(3):498-504.

The vaccinated rabbits produced serum immunoglobulin G and nasal mucosal immunoglobulin A against P. multocida.
1(0,0,0,1) Details
6185529 Greenham LW, Caul EO: Application of potassium thiocyanate as a destaining agent for confirming the specificity of viral immunofluorescence. J Clin Microbiol. 1982 Nov;16(5):803-7.

It was found that KSCN, a chaotropic agent, gave the required destaining but was nonspecific in its action, removing antigen as well as adsorbed immunoglobulins.
1(0,0,0,1) Details
9673263 Jarvinen LZ, Hogenesch H, Suckow MA, Bowersock TL: Induction of protective immunity in rabbits by coadministration of inactivated Pasteurella multocida toxin and potassium thiocyanate extract. Infect Immun. 1998 Aug;66(8):3788-95.

0(0,0,0,0) Details
6212532 Leslie RG: Macrophage interactions with antibodies and soluble immune complexes. . Immunobiology. 1982 Apr;161(3-4):322-33.


In vitro studies aimed at characterising (1) the binding of monomeric immunoglobulins from a variety of animal species to homologous mononuclear phagocytes, (2) the enhancement in phagocyte binding when antibodies are reacted with soluble antigens to form complexes of defined size, (3) the kinetics of complex ingestion and catabolism by macrophages and the biochemical mechanisms involved, (4) the role of complement in soluble complex catabolism and (5) the stimulatory effects of soluble complexes on phagocyte activity are reviewed.
1(0,0,0,1) Details