Protein Information

Name CA1
Synonyms CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III…

Compound Information

Name potassium thiocyanate
CAS potassium thiocyanate

Reference List

PubMed Abstract RScore(About this table)
15895688 Demir Y, Nadaroglu H, Demir N: Purification and characterization of carbonic anhydrase from bovine stomach and effects of some known inhibitors on enzyme activity. J Enzyme Inhib Med Chem. 2005 Feb;20(1):75-80.

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7680260 Kataoka K, Mitani A, Andou Y, Enomoto R, Ogita K, Yoneda Y: Binding of [3H] MK-801, NMDA-displaceable [3H] glutamate, [3H] glycine, [3H] spermidine, [3H] kainate and [3H] AMPA to regionally discrete brain membranes of the gerbil: a biochemical study. Neurochem Int. 1993 Jan;22(1):37-43.


In the gerbil, an almost equivalent level of N-methyl-D-aspartate (NMDA)-displaceable [3H] glutamate binding was found in field CA1 and the dentate gyrus, while approx 30% less in field CA3, a profile which was strikingly similar to that of (+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene-5,10-imin e maleate (MK-801) or of [3H] glycine. [3H] Kainate binding was highest in the dentate gyrus followed by field CA3 and then field CA1, the ratio of the highest to the lowest being 3 to 2.
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17970284 Demir Y, Nadaroglu H, Demir N: Purification and some properties of carbonic anhydrase from Elephas trogontherii (Steppe elephant) bone. Indian J Biochem Biophys. 2007 Aug;44(4):252-6.

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1967632 Nielsen EO, Drejer J, Cha JH, Young AB, Honore T: Autoradiographic characterization and localization of quisqualate binding sites in rat brain using the antagonist [3H] 6-cyano-7-nitroquinoxaline-2,3-dione: comparison with (R,S)-[3H] alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding sites. J Neurochem. 1990 Feb;54(2):686-95.

Using quantitative autoradiography, we have investigated the binding sites for the potent competitive non-N-methyl-D-aspartate (non-NMDA) glutamate receptor antagonist [3H] 6-cyano-7-nitro-quinoxaline-2,3-dione ([3H]-CNQX) in rat brain sections. [3H] CNQX binding was regionally distributed, with the highest levels of binding present in hippocampus in the stratum radiatum of CA1, stratum lucidum of CA3, and molecular layer of dentate gyrus.
Binding of [3H] AMPA to quisqualate receptors in the presence of potassium thiocyanate produced curvilinear Scatchard plots.
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11765905 Demir Y, Demir N, Alayli A: Cytosolic and non-cytosolic carbonic anhydrase enzymes from bovine leukocytes. Prep Biochem Biotechnol. 2001 Nov;31(4):421-31.

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8640342 Hawkins LM, Beaver KM, Jane DE, Taylor PM, Sunter DC, Roberts PJ: Characterization of the pharmacology and regional distribution of (S)-[3H]-5-fluorowillardiine binding in rat brain. Br J Pharmacol. 1995 Oct;116(3):2033-9.

Specific binding represented greater than 80% of the total binding and was increased by 10% in the presence of 100mM potassium thiocyanate (KSCN). 2.
The highest levels of binding were in the dentate gyrus and the CA1 region of the hippocampus.
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