Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name potassium thiocyanate
CAS potassium thiocyanate

Reference List

PubMed Abstract RScore(About this table)
2537211 Bott M, Thauer RK: Proton translocation coupled to the oxidation of carbon monoxide to CO2 and H2 in Methanosarcina barkeri. Eur J Biochem. 1989 Feb 1;179(2):469-72.


Proton extrusion remained unaltered when the proton-translocating ATPase was specifically inhibited by dicyclohexylcarbodiimide.
1(0,0,0,1) Details
8670305 Wojtczak L, Nikitina ER, Czyz A, Skulskii IA: Cuprous ions activate glibenclamide-sensitive potassium channel in liver mitochondria. Biochem Biophys Res Commun. 1996 Jun 14;223(2):468-73.

Cuprous ions at micromolar concentrations induced swelling of rat liver mitochondria in isotonic solutions of potassium thiocyanate and potassium acetate.
In K (+)-containing media, Cu+ collapsed the mitochondrial membrane potential formed by operation of the respiratory chain with succinate or tetramethyl p-phenylenediamine + ascorbate as substrates or by the proton-pumping ATPase.
1(0,0,0,1) Details
1283478 Fukayama H, Nasu M, Murakami S, Sugawara M: Examination of antithyroid effects of smoking products in cultured thyroid follicles: only thiocyanate is a potent antithyroid agent. Acta Endocrinol. 1992 Dec;127(6):520-5.


Iodide uptake, iodine organification, de novo thyroid hormone formation, and iodide efflux were measured in the presence of 0-200 mumol/l nicotine, cotinine, or potassium thiocyanate.
0(0,0,0,0) Details
2527854 Bowman BJ, Dschida WJ, Harris T, Bowman EJ: The vacuolar ATPase of Neurospora crassa contains an F1-like structure. J Biol Chem. 1989 Sep 15;264(26):15606-12.

3(0,0,0,3) Details
6322687 Lopez-Moratalla N, Funes T, Garrido B, Fernandez de Manzanos T, Santiago E: Effect of injected glucagon or fatty acids on mitochondrial ATPase. . Arch Biochem Biophys. 1984 Feb 15;229(1):194-201.


When mitochondria of treated animals were isolated an increase in ATPase activity was observed as well as a modification on the response to activators and inhibitors and to the sulfhydryl reagent N-ethylmaleimide.
2(0,0,0,2) Details
1675566 Fykse EM, Fonnum F: Transport of gamma-aminobutyrate and L-glutamate into synaptic vesicles. Biochem J. 1991 Jun 1;276 ( Pt 2):363-7.


Effect of different inhibitors on the vesicular uptake of neurotransmitters and on the Mg2 (+)-ATPase..
2(0,0,0,2) Details
6126183 Hutton JC: The internal pH and membrane potential of the insulin-secretory granule. . Biochem J. 1982 Apr 15;204(1):171-8.


The effects of ATP were reversed by the protonophore carbonyl cyanide p-trifluoromethoxyphenylhydrazone, the combination of valinomycin, nigericin and K (+), and by the Mg (2+)-dependent ATPase inhibitor tributyltin.
2(0,0,0,2) Details
10987558 Massonneau A, Martinoia E, Dietz KJ, Mimura T: Phosphate uptake across the tonoplast of intact vacuoles isolated from suspension-cultured cells of Catharanthus roseus (L.) G. Planta. 2000 Aug;211(3):390-5.

Orthophosphate uptake was strongly stimulated in the presence of Mg-ATP and Mg-pyrophosphate and inhibited by bafilomycin and concanamycin which are potent inhibitors of the vacuolar H+-ATPase.
Potassium thiocyanate, which dissipates the membrane potential across the tonoplast, strongly inhibited the Mg-ATP-stimulated uptake of Pi, while only a weak inhibition was observed in the presence of NH4Cl, which dissipates the pH gradient.
1(0,0,0,1) Details
6148965 Chen JW, Sun Q, Hwang F: Properties of the membrane-bound Mg2+-ATPase isolated from Acholeplasma laidlawii. Biochim Biophys Acta. 1984 Oct 17;777(1):151-4.

1(0,0,0,1) Details