| 18035410 |
Shi Q, Chen X, Lu T, Jing X: The immobilization of proteins on biodegradable polymer fibers via click chemistry. Biomaterials. 2008 Mar;29(8):1118-26. Epub 2007 Nov 26.
Testis-specific protease 50 (TSP50) was immobilized on ultrafine biodegradable polymer fibers, i.e., (1) to prepare a propargyl-containing polymer P (LA90-co-MPC10) by introducing propargyl group into a cyclic carbonate monomer (5-methyl-5-propargyloxycarbonyl-1,3-dioxan-2-one, MPC) and copolymerizing it with l-lactide; (2) to electrospin the functionalized polymer into ultrafine fibers; (3) to azidize the TSP50, and (4) to perform the click reaction between the propargyl groups on the fibers and the azido groups on the protein. |
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