| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10797567 | Chan WH, Yu JS: Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by J Cell Biochem. 2000 Apr;78(1):73-84. We previously showed that UV irradiation can elicit caspase-3 activation and the subsequent cleavage and activation of p21-activated kinase 2 (PAK2) in human epidermal carcinoma A431 cells. |
2(0,0,0,2) | Details |
| 14709344 | Grammatopoulos TN, Morris K, Bachar C, Moore S, Andres R, Weyhenmeyer JA: Angiotensin II attenuates chemical hypoxia-induced caspase-3 activation in primary cortical neuronal cultures. Brain Res Bull. 2004 Jan 15;62(4):297-303. Treatment with the caspase-3 inhibitor resulted in a dose-dependent decrease in apoptosis, suggesting that sodium azide-induced apoptosis is mediated through a caspase-3 dependent pathway. |
260(2,5,5,10) | Details |
| 10879632 | Kumi-Diaka J, Butler A: Caspase-3 protease activation during the process of -induced apoptosis in TM4 testicular cells. Biol Cell. 2000 Apr;92(2):115-24. The overall results from all the data demonstrated that: i) exerts dose- and time-dependent effects on TM4 testis cells; ii) apoptosis is induced by lower concentrations of and necrosis induced by higher concentrations of iii) induced activation caspase-3 enzymatic activity; iv) -induction of apoptosis and necrosis was significantly inhibited by the caspase-3 inhibitor, z-DEV-FMK; v) sodium azide induced necrosis without activation of CPP32 enzymatic activity, and induction of apoptosis; and vi) -induced apoptosis was associated with activation of CPP32 enzymatic activity in the cells. |
85(1,1,1,5) | Details |
| 15500948 | Ding X, Xu Q, Liu F, Zhou P, Gu Y, Zeng J, An J, Dai W, Li X: monomethyl ether photodynamic damage on HeLa cells by means of reactive species production and cytosolic free concentration elevation. Cancer Lett. 2004 Dec 8;216(1):43-54. Sodium azide (the singlet quencher) or (the scavenger) could protect HeLa cells from the apoptosis and necrosis induced by HMME-PDT, showing that reactive species (ROS), such as singlet and played a decisive role in HMME-PDT-induced HeLa cells death. Cytochrome C (Cyto C) release from mitochondria into cytosol and Caspase-3 activation after HMME-PDT were inhibited by BAPTA/AM (an intracellular chelator). |
2(0,0,0,2) | Details |
| 15082229 | Cho S, Liu D, Fairman D, Li P, Jenkins L, McGonigle P, Wood A: Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures. Neurochem Int. 2004 Jul;45(1):117-27. In order to ascertain the existence of the synaptic pool of sister cultures were treated with sodium azide. Further studies revealed a time-dependent activation of caspase 3 following OGD, shown by immunoblot analysis as well as by confocal laser scanning microscopy. |
1(0,0,0,1) | Details |
| 12954857 | Garnier P, Ying W, Swanson RA: Ischemic preconditioning by caspase cleavage of poly (ADP- polymerase-1. J Neurosci. 2003 Sep 3;23(22):7967-73. Preconditioning also produced an increase in activated caspase-3 peptide and an increase in caspase-3 activity in the cortical cultures. |
1(0,0,0,1) | Details |
| 10597238 | Suzuki S, Higuchi M, Proske RJ, Oridate N, Hong WK, Lotan R: Implication of mitochondria-derived reactive species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl) retinamide-induced apoptosis in cervical carcinoma cells. Oncogene. 1999 Nov 4;18(46):6380-7. |
2(0,0,0,2) | Details |
| 10764744 | Bai J, Cederbaum AI: Overexpression of catalase in the mitochondrial or cytosolic compartment increases sensitivity of HepG2 cells to tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2000 Jun 23;275(25):19241-9. The activities of caspase-3 and -8 were increased by TNF-alpha, with the highest activities found in mC5 cells. Sodium azide, an inhibitor of catalase, reduced the increased sensitivity of mC5 and C33 cells to TNF-alpha to the level of toxicity found with control Hp cells. |
2(0,0,0,2) | Details |
| 20032508 | Endale M, Kim SD, Lee WM, Kim S, Suk K, Cho JY, Park HJ, Wagley Y, Kim S, Oh JW, Rhee MH: Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes. Am J Physiol Cell Physiol. 2010 Mar;298(3):C611-23. Epub 2009 Dec 23. It significantly increased annexin V-positive cells, cleaved caspase-3, and enhanced DNA ladder formation and cell cycle arrest. A marked increase in RGS2 occurred after ischemic stress induced by chemicals (sodium azide and 2-deoxyglucose) or - deprivation (OGD, real ischemia). |
2(0,0,0,2) | Details |
| 20036216 | Hur J, Lee P, Kim MJ, Kim Y, Cho YW: Ischemia-activated microglia induces neuronal injury via activation of gp91phox oxidase. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1526-30. Epub 2009 Dec 28. MCM-treated SH-SY5Y cells showed reduced the viability, increased caspase-3 activity, decreased Bcl-2/Bax ratio, and increased cytochrome c release, increased inflammatory cytokines, and increased reactive species (ROS) generation. |
1(0,0,0,1) | Details |
| 17531242 | Nabata A, Kuroki M, Ueba H, Hashimoto S, Umemoto T, Wada H, Yasu T, Saito M, Momomura S, Kawakami M: C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque. Atherosclerosis. 2008 Jan;196(1):129-35. Epub 2007 May 24. However, recent in vitro studies raised the possibility that the effects of CRP are caused by biologically active contaminants such as sodium azide and endotoxin. In human endothelial cells, CRP significantly inhibited cell proliferation and increased endothelial cell apoptosis evaluated by terminal deoxynucleotidyltransferase-mediated nick end labeling and caspase-3 activity assay, which is reversed by a function-blocking antibody to Fc gamma RIIIB by 78%. |
1(0,0,0,1) | Details |
| 14578187 | Heilig C, Brosius F, Siu B, Concepcion L, Mortensen R, Heilig K, Zhu M, Weldon R, Wu G, Conner D: Implications of transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress. Am J Pathol. 2003 Nov;163(5):1873-85. Caspase-3 activity was 76% higher in GT1 (+/-) versus GT1 (+/+) at 2 hours. |
1(0,0,0,1) | Details |
| 18948185 | Woo HD, Kim BM, Kim YJ, Lee YJ, Kang SJ, Cho YH, Choi JY, Chung HW: prevents necrotic cell death induced by co-exposure to benzo (a) pyrene and UVA radiation. Toxicol In Vitro. 2008 Dec;22(8):1840-5. Epub 2008 Oct 7. Intracellular reactive species (ROS) levels were increased significantly in the co-exposed cells, and treatment with the polyphenol but not with sodium azide or decreased ROS levels and increased cell viability in BaP/UVA-treated cells. |
0(0,0,0,0) | Details |