Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
12415870 Fujimura T, Kobayashi H, Suzuki T, Sato I, Hara S: [Neurotoxicity in sodium azide poisoning] . 198-9.

Measurements of the activities of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT), enzymes that hydrolyze and synthesize acetylcholine (ACh) and high-affinity choline uptake (HACU), a rate-limiting step in the synthesis of ACh, were determined in the presence of various concentrations of sodium azide in vitro.
37(0,1,2,2) Details
10471290 Weiner L, Roth E, Mazur Y, Silman I: Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. Chudoku Kenkyu. 2002 Jul;15(3):281-8.

Both anaerobiosis and sodium azide greatly reduce the extent of cross-linking, suggesting that singlet oxygen is responsible for the phenomenon.
3(0,0,0,3) Details
15143516 Tuhai VA, Danylovych IuV: [Enzymes and processes of activation of the endometrium stromal cells] . Neurosci Lett. 2000 Jul 21;288(3):203-6.

The endometrium stroma cells and properties of such key enzymes as acetylcholinesterase, Mg2+, Ca (2+)-ATPase, AMP-deaminase have been investigated in them.
Common Mg2+, Ca (2+)-ATPase activity of compounds of 36 +/- 2 mumol Pi/mg protein/hour, is depressed by sodium azide and thapsigargine, that specifies presence of an investigated enzyme in mitochondria and endoplasmic reticulum of investigated cells.
2(0,0,0,2) Details
17590992 Jamal M, Ameno K, Ikuo U, Kumihashi M, Wang W, Ijiri I: Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain. Novartis Found Symp. 2007;285:137-41; discussion 141-4

The results showed that acetaldehyde was present in the cyanamide (CY) + EtOH, CY + 4-methylpyrazole (4-MP) + EtOH and CY + sodium azide + EtOH groups.
Second, the effects of EtOH and acetaldehyde on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were investigated in the frontal cortex and hippocampus of high acetaldehyde-producing rats using RT-PCR and Western blot.
1(0,0,0,1) Details
10889343 Hedin HL, Fowler CJ: Effects of sodium azide on the secretion of soluble amyloid-beta precursor protein and the accumulation of beta-amyloid (1-40) in cultured chick neurons. Biochemistry. 1999 Aug 31;38(35):11401-5.

However, NaN (3) reduced the accumulation of Abeta (1-40) in the cell lysates and decreased the acetylcholine esterase activity both in cell culture media and in cell lysates.
1(0,0,0,1) Details