Protein Information

Name succinate dehydrogenase (protein family or complex)
Synonyms Succinate dehydrogenase; Succinate dehydrogenases

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
12676762 Paddenberg R, Ishaq B, Goldenberg A, Faulhammer P, Rose F, Weissmann N, Braun-Dullaeus RC, Kummer W: Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L710-9. Epub 2003 Jan 10.


Histochemically demonstrable succinate dehydrogenase activity of complex II in the arterial wall decreased during hypoxia.
2(0,0,0,2) Details
11080215 Talpade DJ, Greene JG, Higgins DS Jr, Greenamyre JT: In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3) H] dihydrorotenone. J Neurochem. 2000 Dec;75(6):2611-21.


There was an excellent correlation between regional levels of in vivo [(3) H] DHR binding and the in vitro activities of complex II (succinate dehydrogenase) and complex IV (cytochrome oxidase), suggesting that the stoichiometry of these components of the electron transport chain is relatively constant across brain regions.
1(0,0,0,1) Details
10888471 Rustenbeck I, Dickel C, Herrmann C, Grimmsmann T: Mitochondria present in excised patches from pancreatic B-cells may form microcompartments with ATP-dependent potassium channels. Biosci Rep. 1999 Apr;19(2):89-98.

This effect was antagonized by the inhibitor of cytochrome oxidase, sodium azide (5 mM).
Likewise, the inhibitor of succinate dehydrogenase, malonate (5 mM), increased the open probability of K (ATP) channels in the presence of succinate (1 mM).
1(0,0,0,1) Details