| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16223554 | Gomes-Carneiro MR, Dias DM, Paumgartten FJ: Study on the mutagenicity and antimutagenicity of beta-ionone in the Salmonella/microsome assay. Food Chem Toxicol. 2006 Apr;44(4):522-7. Epub 2005 Oct 11. It has been reported that, in the rat liver, activation of B [a] P and 2-AF depend on CYP1A1 activity, and that CYP2B subfamily is involved in the metabolic activation of CP and Antimutagenic activity was investigated by testing (by the plate incorporation method) different non-toxic doses of BIO against one or more non-toxic doses of direct-acting (sodium azide: SA, 4-nitroquinoline-N-oxide: 4-NQNO, 2-nitrofluorene: 2-NF and nitro-o-phenylenediamine: NPD) as well as indirect-acting (cyclophosphamide: CP, benzo [a] pyrene: B [a] P, 2-aminoanthracene: 2-AA, and 2-aminofluorene: 2-AF) mutagens. |
2(0,0,0,2) | Details |
| 15936245 | Gomes-Carneiro MR, Dias DM, De-Oliveira AC, Paumgartten FJ: Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay. Mutat Res. 2005 Aug 1;585(1-2):105-12. Since CYP2B1 converts and CP into mutagenic metabolites, and CYP1A1 activates B [a] P, 2-AA and 2-AF, results suggest that BISA-induced antimutagenicity could be mediated by an inhibitory effect on the metabolic activation of these promutagens. In the antimutagenicity assays, BISA was tested up to the highest nontoxic dose (i.e. 50 and 150 microg/plate, with and without S9 mix, respectively) against direct-acting (sodium azide, SA; 4-nitroquinoline-N-oxide, 4-NQNO; 2-nitrofluorene, 2-NF; and nitro-o-phenylenediamine, NPD) as well as indirect-acting (cyclophosphamide, CP; benzo [a] pyrene, B [a] P; 2-aminoanthracene, 2-AA; and 2-aminofluorene, 2-AF) mutagens. |
1(0,0,0,1) | Details |
| 17870654 | Lazarou D, Grougnet R, Papadopoulos A: Antimutagenic properties of a polyphenol-enriched extract derived from sesame-seed perisperm. Mutat Res. 2007 Dec 1;634(1-2):163-71. Epub 2007 Aug 3. A polyphenolic mixture derived from sesame-seed perisperm (SSP) strongly reduced the mutagenicity of peroxide (H (2) O (2)), sodium azide (NaN (3)), and benzo [a] pyrene (BaP) in strains TA100 and/or TA98 of Salmonella typhimurium. According to in vitro experiments the polyphenolic mixture inhibited the activity of the CYP1A1 (EROD) enzyme responsible for the activation of BaP in the Ames' test, as well as that of the cytosolic enzyme GST. |
1(0,0,0,1) | Details |
| 9918136 | Williams JA, Stone EM, Millar BC, Gusterson BA, Grover PL, Phillips DH: Determination of the enzymes responsible for activation of the heterocyclic amine 2-amino-3-methylimidazo [4,5-f] quinoline in the human breast. Pharmacogenetics. 1998 Dec;8(6):519-28. Adduct formation in stimulated neutrophils was inhibited 80% by the myeloperoxidase inhibitor sodium azide (1 mM) but was not affected by proadifen (100 microM), indomethacin (100 microM), or eicosatetraynoic acid (100 microM), inhibitors of cytochrome P450, prostaglandin synthetase, and lipoxygenase, respectively. |
0(0,0,0,0) | Details |