| Name | organic cation transporter |
|---|---|
| Synonyms | HIMTP; Organic cation transporter; Putative UST1 like organic anion transporter; Putative integral membrane transport protein; UST 6; UST6; Putative UST1 like organic anion transporters; Putative integral membrane transport proteins |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18606742 | Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y: Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of Drug Metab Dispos. 2008 Oct;36(10):2005-13. Epub 2008 Jul 7. The transport was inhibited by metabolic inhibitors (rotenone and sodium azide) but was insensitive to extracellular and membrane potential for both substrates. |
2(0,0,0,2) | Details |
| 17604344 | Iwakiri T, Okumura M, Hidaka M, Kumagai Y, Ichihara E, Kawano Y, Arimori K: Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes. J Appl Toxicol. 2008 Apr;28(3):329-36. The uptake of epirubicin at a clinical concentration (7.5 x 10 (-7) M) was significantly reduced at 4 degrees C and significantly inhibited when pretreated with metabolic inhibitors (carbonyl p-trifluoromethoxyphenylhydrazone (FCCP), rotenone and sodium azide) by nearly 25%. Furthermore, an organic anion transporter inhibitor, namely, 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid (DIDS); organic anion transport substrates, namely, (PAH), and 17-beta-D- and organic cation transporter inhibitors, namely, and tetraethylammonium significantly reduced the uptake of epirubicin. |
1(0,0,0,1) | Details |
| 10504033 | Yokogawa K, Miya K, Tamai I, Higashi Y, Nomura M, Miyamoto K, Tsuji A: Characteristics of transport in cultured human hepatoma HLF cells. J Pharm Pharmacol. 1999 Aug;51(8):935-40. The recently cloned organic cation transporter, OCTN2, isolated as a homologue of OCTN1, has been shown to be of physiological importance in the renal tubular reabsorption of filtered as a high-affinity Na+ transporter in man. The high affinity transporter was significantly inhibited by metabolic inhibitors (sodium azide, dinitrophenol, iodoacetic acid) and at low temperature (4 degrees C). |
1(0,0,0,1) | Details |
| 17015968 | Sakanaka K, Kawazu K, Nishida K, Nakamura J, Nakashima M, Nakamura T, Oshita A, Ichikawa N, Sasaki H: Transport of timolol and tilisolol in rabbit corneal epithelium. Biol Pharm Bull. 2006 Oct;29(10):2143-7. The transcellular permeability of tilisolol from the apical to the basal side was inhibited by sodium azide, tetraethylammonium, quinidine, and Tilisolol had an active mechanism in uptake to the corneal epithelium, probably by the organic cation transporter family, although timolol predominantly permeated via passive diffusion. |
1(0,0,0,1) | Details |
| 10467961 | Sawada N, Takanaga H, Matsuo H, Naito M, Tsuruo T, Sawada Y: uptake by mouse brain capillary endothelial cells in culture. J Pharm Pharmacol. 1999 Jul;51(7):847-52. Various basic drugs and endogenous substances, including substrates and inhibitors of the organic cation transporter, significantly inhibited the [3H] uptake. |
1(0,0,0,1) | Details |