| Name | TIMP 1 |
|---|---|
| Synonyms | CLGI; Collagenase inhibitor; EPA; EPO; Erythroid potentiating activity; Fibroblast collagenase inhibitor; HCI; Metalloproteinase inhibitor 1… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12542540 | Karrer S, Bosserhoff AK, Weiderer P, Landthaler M, Szeimies RM: Influence of and red light on collagen metabolism of human dermal fibroblasts. J Invest Dermatol. 2003 Feb;120(2):325-31. Addition of nontoxic concentrations of sodium azide, a singlet- quencher, significantly inhibited induction of matrix metalloproteinase 1 by and light. Cell supernatants were taken 6-72 h after photodynamic therapy to determine protein levels of the matrix metalloproteinases 1, 2, and 3, and of their inhibitors, tissue inhibitor of metalloproteinase 1 and 2 by enzyme-linked immunosorbent assay. |
1(0,0,0,1) | Details |
| 8751977 | Herrmann G, Wlaschek M, Bolsen K, Prenzel K, Goerz G, Scharffetter-Kochanek K: Photosensitization of uroporphyrin augments the ultraviolet A-induced synthesis of matrix metalloproteinases in human dermal fibroblasts. J Invest Dermatol. 1996 Sep;107(3):398-403. In this study, we therefore asked whether long-wave ultraviolet irradiation (340-450 nm) in conjunction with could modulate the synthesis of MMPs with substrate specificities for dermal (collagens I, III, V; proteoglycans) and basement membrane components (collagens IV, VII; fibronectin; laminin) and whether synthesis of the counteracting tissue inhibitor of metalloproteinases is also affected. Using deuterium oxide as enhancer and sodium azide as quencher of singlet we could increase or reduce MMP synthesis, suggesting that singlet is the major intermediate in the upregulation of MMPs after irradiation of uroporphyrin-pretreated fibroblasts. |
2(0,0,0,2) | Details |
| 10836612 | Yin L, Morita A, Tsuji T: Alterations of extracellular matrix induced by tobacco smoke extract. Arch Dermatol Res. 2000 Apr;292(4):188-94. Sodium azide, and Trolox (a water-soluble prevented both the UVA1- and the tobacco-induced alteration of MMP-1. The expression of MMP and TIMP was analyzed semiquantitatively following reverse transcriptase-polymerase chain reaction. |
2(0,0,0,2) | Details |
| 8375513 | Scharffetter-Kochanek K, Wlaschek M, Briviba K, Sies H: Singlet induces collagenase expression in human skin fibroblasts. . FEBS Lett. 1993 Oct 4;331(3):304-6. The effect is enhanced in deuterium oxide-based medium and is abolished in the presence of non-toxic doses of sodium azide. In contrast, the mRNA level of the tissue inhibitor of metalloproteinases (TIMP-1) remains unaltered under these experimental conditions. |
2(0,0,0,2) | Details |
| 7829875 | Wlaschek M, Briviba K, Stricklin GP, Sies H, Scharffetter-Kochanek K: Singlet may mediate the ultraviolet A-induced synthesis of interstitial collagenase. J Invest Dermatol. 1995 Feb;104(2):194-8. In contrast, mRNA levels of TIMP-1, the specific tissue inhibitor of metalloproteinases, remained unchanged. In contrast, sodium azide, a potent quencher of singlet almost totally abrogated the induction of collagenase after exposure of fibroblasts to NDPO2 or to UVA irradiation. |
2(0,0,0,2) | Details |