Protein Information

Name monoamine oxidases
Synonyms Adrenalin oxidase; Amine oxidase; Amine oxidase [flavin containing] B; MAO B; MAOB; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type B…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
7931250 Barwell CJ, Ebrahimi SA: Some problems associated with measuring monoamine oxidase activity in the presence of sodium azide. J Neural Transm Suppl. 1994;41:35-9.

The colourimetric assay of monoamine oxidase activity, as hydrogen peroxide production, normally requires the use of sodium azide to inhibit breakdown of hydrogen peroxide by catalase.
168(2,2,3,3) Details
10092944 Zajoncova L, Frebort I, Luhova L, Sebela M, Galuszka P, Pec P: Comparison of kinetic properties of amine oxidases from sainfoin and lentil and immunochemical characterization of copper/quinoprotein amine oxidases. Biochem Mol Biol Int. 1999 Jan;47(1):47-61.

Both amine oxidases, like other plant Cu-amine oxidases, were inhibited by substrate analogs (1,5-diamino-3-pentanone, 1,4-diamino-2-butanone and aminoguanidine), Cu2+ chelating agents (diethyltriamine, 1,10-phenanthroline, 8-hydroxyquinoline, 2,2'-bipyridyl, imidazole, sodium cyanide and sodium azide), some alkaloids (L-lobeline and cinchonine), some lathyrogens (beta-aminopropionitrile and aminoacetonitrile) and other inhibitors (benzamide oxime, acetone oxime, hydroxylamine and pargyline).
33(0,1,1,3) Details
15052604 Mazzio EA, Soliman KF: Glioma cell antioxidant capacity relative to reactive oxygen species produced by dopamine. J Appl Toxicol. 2004 Mar-Apr;24(2):99-106.

We investigate glial antioxidant enzyme systems relative to ROS generated during cytokine activation, monoamine oxidase (MAO) activity and autoxidation of DA in glioma cells.
Preincubation with sodium azide but not buthionine-[S, R]-sulfoximine attenuated this response, indicating catalase as the primary enzyme responsible for this effect.
1(0,0,0,1) Details
17580085 Luques L, Shoham S, Weinstock M: Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: prevention by ladostigil. Exp Neurol. 2007 Aug;206(2):209-19. Epub 2007 Apr 27.

The present study replicated the reduction in brain COx activity in rats by administering sodium azide (NaN (3)) for 4 weeks via Alzet minipumps at the rate of 1 mg/kg/h, and determined its effect on hippocampal cholinergic transmission, spatial and episodic memory.
Chronic treatment with ladostigil, a novel cholinesterase and monoamine oxidase inhibitor, prevented the decrease in ChAT in the diagonal band, the compensatory increase in synaptic plasticity and TfR and the memory deficits without restoring COx activity.
1(0,0,0,1) Details
9275283 Zemskova MA, Axenova LN, Medvedev AE: The influence of some compounds commonly used in biochemical studies of mitochondria on the activity of monoamine oxidases. Biochemistry. 1997 Apr;62(4):448-9.

It was previously described that low concentrations of sodium azide monoamine oxidase (MAO) B assayed by spectrophotometric measurement of benzaldehyde or by hydrogen peroxide accumulation.
7(0,0,1,2) Details
8216383 O'Brien EM, Kiely KA, Tipton KF: A discontinuous luminometric assay for monoamine oxidase. . Biochem Pharmacol. 1993 Oct 5;46(7):1301-6.

2(0,0,0,2) Details