Protein Information

Name transferrin receptor
Synonyms CD71; p90; TR; CD71 antigen; T9; TFR; TFR 1; TFR1…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
16360136 Li YQ, Liu B, Zhao CG, Zhang W, Yang BS: Characterization of transferrin receptor-dependent GaC-Tf-FeN transport in human leukemic HL60 cells. Clin Chim Acta. 2006 Apr;366(1-2):225-32. Epub 2005 Dec 15.

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17580085 Luques L, Shoham S, Weinstock M: Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: prevention by ladostigil. Exp Neurol. 2007 Aug;206(2):209-19. Epub 2007 Apr 27.

The present study replicated the reduction in brain COx activity in rats by administering sodium azide (NaN (3)) for 4 weeks via Alzet minipumps at the rate of 1 mg/kg/h, and determined its effect on hippocampal cholinergic transmission, spatial and episodic memory.
NaN (3) also induced a significant increase in vesicular acetylcholine transporter (VAChT)-immunoreactive varicosities, GAP-43 in the subgranular layer and of transferrin receptors (TfR) in the hilus of the dentate gyrus.
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14517218 Potocky TB, Menon AK, Gellman SH: Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. J Biol Chem. 2003 Dec 12;278(50):50188-94. Epub 2003 Sep 29.

Endocytic entry of the peptides was blocked by the energy poisons sodium azide and 2-deoxyglucose, whereas staining of the nucleus (nucleolus), but not endocytic vesicles, was abrogated by treating the cells with ammonium chloride.
Using fluorescence confocal microscopy, we show that when added to cells, both peptides are found in endocytic vesicles containing the transferrin receptor as well as in the cytoplasm and nucleus (TAT-(47-57)) or nucleolus (beta-(VRR) 4).
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9673237 Modun B, Evans RW, Joannou CL, Williams P: Receptor-mediated recognition and uptake of iron from human transferrin by Staphylococcus aureus and Staphylococcus epidermidis. Infect Immun. 1998 Aug;66(8):3591-6.

To determine whether the staphylococcal transferrin receptor is involved in the removal of iron from transferrin, we employed 6 M urea-polyacrylamide gel electrophoresis, which separates human transferrin into four forms (diferric, monoferric N-lobe, and monoferric C-lobe transferrin and apotransferrin).
Metabolic poisons such as sodium azide and nigericin inhibited the release of iron from human transferrin, indicating that it is an energy-requiring process.
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7608173 Stockert RJ, Potvin B, Tao L, Stanley P, Wolkoff AW: Human hepatoma cell mutant defective in cell surface protein trafficking. J Biol Chem. 1995 Jul 7;270(27):16107-13.

Pretreatment with monensin, sodium azide, or colchicine reduced surface binding of 125I-ASOR in HuH-7 cells by 50% but had no effect on binding to Trf1 cells.
Similar results were obtained with the transferrin receptor.
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