Protein Information

Name L selectin
Synonyms CD62 antigen ligand; CD62L; CD62L antigen; HLHRC; L selectin; L selectin precursor; LAM 1; LAM1…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
11290767 Leid JG, Steeber DA, Tedder TF, Jutila MA: Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. J Immunol. 2001 Apr 15;166(8):4899-907.

The induced conformational change occurred at 37 degrees C, at 4 degrees C, in the presence of sodium azide and tyrosine kinase inhibitors herbimycin A and genistein, and with soluble detergent-extracted L-selectin.
87(1,1,1,7) Details
11071659 Gomez-Gaviro MV, Dominguez-Jimenez C, Carretero JM, Sabando P, Gonzalez-Alvaro I, Sanchez-Madrid F, Diaz-Gonzalez F: Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration. Blood. 2000 Nov 15;96(10):3592-600.

9(0,0,0,9) Details
7513201 Yeo EL, Sheppard JA, Feuerstein IA: Role of P-selectin and leukocyte activation in polymorphonuclear cell adhesion to surface adherent activated platelets under physiologic shear conditions (an injury vessel wall model). Blood. 1994 May 1;83(9):2498-507.

Adherent PMNs appeared morphologically activated and flow cytometric analysis of adherent PMNs confirmed activation because CD11b and CD18 surface expression was upregulated (100% and 27%, respectively), whereas L-selectin was downregulated (55%) compared with control nonadherent PMNs.
In the presence of the metabolic inhibitor sodium azide (0.02% and 0.1%) there was a 23% +/- 9% and 51% +/- 3% decrease, respectively, in PMN adhesion at 100 s-1.
1(0,0,0,1) Details